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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 19282453 are 2160
    Results from 275 - 300
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM0277
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    Altritol nucleic acid
    18,19 * 22
    3,6,14,18,20,21
    Sugar
    Sugar
    76 percent target mRNA inhibition
    19282453
    SM0278
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    Altritol nucleic acid
    5,8,11,14,17 * 22
    3,6,14,18,20,21
    Sugar
    Sugar
    4.3 percent target mRNA inhibition
    19282453
    SM0279
    GACGUAAACGGCCACAAGUUCU
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid
    Altritol nucleic acid
    20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    70.3 percent target mRNA inhibition
    19282453
    SM0280
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    Altritol nucleic acid
    19,20
    3,6,14,18,20,21
    Sugar
    Sugar
    74.9 percent target mRNA inhibition
    19282453
    SM0281
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    Altritol nucleic acid
    1,2,3,18,19,20 * 21
    3,6,14,18,20,21
    Sugar
    Sugar
    77 percent target mRNA inhibition
    19282453
    SM0282
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    Altritol nucleic acid
    5,8,11,14 * 21
    3,6,14,18,20,21
    Sugar
    Sugar
    30.7 percent target mRNA inhibition
    19282453
    SM0283
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    Altritol nucleic acid
    5,8,11,14,19,20 * 21
    3,6,14,18,20,21
    Sugar
    Sugar
    36.6 percent target mRNA inhibition
    19282453
    SM0284
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethoxymethyl* 2-Deoxy
    Altritol nucleic acid
    19,20 * 21
    3,6,14,18,20,21
    Sugar
    Sugar
    79.6 percent target mRNA inhibition
    19282453
    SM0285
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethoxymethyl* 2-Deoxy
    Altritol nucleic acid
    3,5,9,19,20 * 21
    3,6,14,18,20,21
    Sugar
    Sugar
    51.6 percent target mRNA inhibition
    19282453
    SM0286
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminopropoxymethyl* 2-Deoxy
    Altritol nucleic acid
    19,20 * 21
    3,6,14,18,20,21
    Sugar
    Sugar
    77.5 percent target mRNA inhibition
    19282453
    SM0287
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminopropoxymethyl* 2-Deoxy
    Altritol nucleic acid
    3,5,9,19,20 * 21
    3,6,14,18,20,21
    Sugar
    Sugar
    37 percent target mRNA inhibition
    19282453
    SM0288
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    Altritol nucleic acid
    16,18
    3,6,14,18,20,21
    Sugar
    Sugar
    80.3 percent target mRNA inhibition
    19282453
    SM0289
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    Altritol nucleic acid
    2,4
    3,6,14,18,20,21
    Sugar
    Sugar
    76.6 percent target mRNA inhibition
    19282453
    SM0290
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Fluoro* 2-O-Methyl
    Altritol nucleic acid
    1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
    3,6,14,18,20,21
    Sugar
    Sugar
    12.5 percent target mRNA inhibition
    19282453
    SM0291
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    Altritol nucleic acid
    20
    3,6,14,18,20,21
    Sugar
    Sugar
    80.8 percent target mRNA inhibition
    19282453
    SM0292
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    Altritol nucleic acid
    19
    3,6,14,18,20,21
    Sugar
    Sugar
    78.3 percent target mRNA inhibition
    19282453
    SM0293
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    Altritol nucleic acid
    5,19,20
    3,6,14,18,20,21
    Sugar
    Sugar
    46.6 percent target mRNA inhibition
    19282453
    SM0294
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Altritol nucleic acid
    3,9,15,20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    74.3 percent target mRNA inhibition
    19282453
    SM0295
    GACGUAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    Altritol nucleic acid
    19,20
    3,6,14,18,20,21
    Sugar
    Sugar
    71.7 percent target mRNA inhibition
    19282453
    SM0296
    GACGTAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    Altritol nucleic acid
    5,19,20
    3,6,14,18,20,21
    Sugar
    Sugar
    76.5 percent target mRNA inhibition
    19282453
    SM0297
    GACGUAAACG + GCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Altritol nucleic acid
    3,9,13,15,20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    76.7 percent target mRNA inhibition
    19282453
    SM0298
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    Altritol nucleic acid
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,22 * 20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    22.8 percent target mRNA inhibition
    19282453
    SM0299
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    Altritol nucleic acid
    1,2,4,5,7,8,10,11,13,14,16,17,19,22 * 3,6,9,12,15,18,20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    22.6 percent target mRNA inhibition
    19282453
    SM0300
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    Altritol nucleic acid
    1,3,5,7,8,9,11,13,15,17,19,22 * 2,4,6,10,12,14,16,18,20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0301
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Altritol nucleic acid
    5,20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    68.6 percent target mRNA inhibition
    19282453