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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 19282453 are 2160
    Results from 150 - 175
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM0152
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    2-Aminopropoxymethyl* 2-Deoxy
    Altritol nucleic acid
    3,5,9,19,20 * 21
    1,2
    Sugar
    Sugar
    22.4 percent target mRNA inhibition
    19282453
    SM0153
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Oxetane-Locked nucleic acid
    Altritol nucleic acid
    16,18
    1,2
    Sugar
    Sugar
    62.6 percent target mRNA inhibition
    19282453
    SM0154
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Oxetane-Locked nucleic acid
    Altritol nucleic acid
    2,4
    1,2
    Sugar
    Sugar
    49.6 percent target mRNA inhibition
    19282453
    SM0155
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Fluoro* 2-O-Methyl
    Altritol nucleic acid
    1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
    1,2
    Sugar
    Sugar
    52.7 percent target mRNA inhibition
    19282453
    SM0156
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    Altritol nucleic acid
    20
    1,2
    Sugar
    Sugar
    60.2 percent target mRNA inhibition
    19282453
    SM0157
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    Altritol nucleic acid
    19
    1,2
    Sugar
    Sugar
    56.3 percent target mRNA inhibition
    19282453
    SM0158
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    Altritol nucleic acid
    5,19,20
    1,2
    Sugar
    Sugar
    39.4 percent target mRNA inhibition
    19282453
    SM0159
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Altritol nucleic acid
    3,9,15,20,21
    1,2
    Sugar
    Sugar
    8.4 percent target mRNA inhibition
    19282453
    SM0160
    GACGUAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGC
    4-C-Hydroxymethyl Deoxyribonucleic acid
    Altritol nucleic acid
    19,20
    1,2
    Sugar
    Sugar
    47.4 percent target mRNA inhibition
    19282453
    SM0161
    GACGTAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGC
    4-C-Hydroxymethyl Deoxyribonucleic acid
    Altritol nucleic acid
    5,19,20
    1,2
    Sugar
    Sugar
    57.5 percent target mRNA inhibition
    19282453
    SM0162
    GACGUAAACG + GCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Altritol nucleic acid
    3,9,13,15,20,21
    1,2
    Sugar
    Sugar
    50.1 percent target mRNA inhibition
    19282453
    SM0163
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGC
    2-Deoxy* Locked nucleic acid
    Altritol nucleic acid
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,22 * 20,21
    1,2
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0164
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGC
    2-Deoxy* Locked nucleic acid
    Altritol nucleic acid
    1,2,4,5,7,8,10,11,13,14,16,17,19,22 * 3,6,9,12,15,18,20,21
    1,2
    Sugar
    Sugar
    4.4 percent target mRNA inhibition
    19282453
    SM0165
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGC
    2-Deoxy* Locked nucleic acid
    Altritol nucleic acid
    1,3,5,7,8,9,11,13,15,17,19,22 * 2,4,6,10,12,14,16,18,20,21
    1,2
    Sugar
    Sugar
    3.8 percent target mRNA inhibition
    19282453
    SM0166
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Altritol nucleic acid
    5,20,21
    1,2
    Sugar
    Sugar
    36.7 percent target mRNA inhibition
    19282453
    SM0167
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Altritol nucleic acid
    3,5,7,9,20,21
    1,2
    Sugar
    Sugar
    2.2 percent target mRNA inhibition
    19282453
    SM0168
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Altritol nucleic acid
    3,9,13,15,20,21
    1,2
    Sugar
    Sugar
    3 percent target mRNA inhibition
    19282453
    SM0169
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    4-C-Hydroxymethyl Deoxyribonucleic acid
    Altritol nucleic acid
    20,21
    1,2
    Sugar
    Sugar
    59.4 percent target mRNA inhibition
    19282453
    SM0170
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    4-C-Hydroxymethyl Deoxyribonucleic acid
    Altritol nucleic acid
    3,5,9,13,20,21
    1,2
    Sugar
    Sugar
    44.1 percent target mRNA inhibition
    19282453
    SM0171
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Alfa-L-Locked nucleic acid
    Altritol nucleic acid
    20,21
    1,2
    Sugar
    Sugar
    54.8 percent target mRNA inhibition
    19282453
    SM0172
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Alfa-L-Locked nucleic acid
    Altritol nucleic acid
    3,9,15,20,21
    1,2
    Sugar
    Sugar
    54.4 percent target mRNA inhibition
    19282453
    SM0173
    GACGUAAACGGCCACAAGUUTU
    ACUUGUGGCCGUUUACGUCGC
    4-C-Hydroxymethyl Deoxyribonucleic acid
    Altritol nucleic acid
    21
    1,2
    Sugar
    Sugar
    60.6 percent target mRNA inhibition
    19282453
    SM0174
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    Altritol nucleic acid
    5,20 * 21
    1,2
    Sugar
    Sugar
    25.5 percent target mRNA inhibition
    19282453
    SM0175
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    UnLocked nucleic acid* Locked nucleic acid
    Altritol nucleic acid
    5 * 20,21
    1,2
    Sugar
    Sugar
    8.3 percent target mRNA inhibition
    19282453
    SM0176
    GACGUAAACCGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    UnLocked nucleic acid* Locked nucleic acid
    Altritol nucleic acid
    10 * 21,22
    1,2
    Sugar
    Sugar
    7.2 percent target mRNA inhibition
    19282453