Browse By

Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 22253019 are 360
    Results from 100 - 125
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM5058
    UCAUCACACUGAAUACCAAUU
    UUGGUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    95.39 percent target mRNA inhibition
    22253019
    SM5059
    UCAUCACACUGAAUACCAAUU
    TTGGTATTCAGTGTGATGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    83.65 percent target mRNA inhibition
    22253019
    SM5060
    UCAUCACACUGAAUACCAAUU
    UUGGUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    91.93 percent target mRNA inhibition
    22253019
    SM5061
    UCAUCACACUGAAUACCAAUU
    UUGGUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14
    Base; Sugar; Sugar
    Sugar
    96.57 percent target mRNA inhibition
    22253019
    SM5062
    UCAUCACACUGAAUACCAAUU
    UUGGUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,5,7,8,9,12,14,17 * 3,4,6,10,11,13,15,16,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    94.33 percent target mRNA inhibition
    22253019
    SM5063
    UCAUCACACUGAAUACCAAUU
    UUGGUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,5,7,8,9,12,14,17 * 3,4,6,10,11,13,15,16,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    92.58 percent target mRNA inhibition
    22253019
    SM5064
    UCAUCACACUGAAUACCAAUU
    UUGGUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,5,7,8,9,12,14,17 * 3,4,6,10,11,13,15,16,18,19,20,21
    Base; Sugar; Sugar
    Sugar
    93.59 percent target mRNA inhibition
    22253019
    SM5065
    UCAUCACACUGAAUACCAAUU
    UUGGUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,5,7,8,9,12,14,17 * 3,4,6,10,11,13,15,16,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    87.9 percent target mRNA inhibition
    22253019
    SM5066
    UCAUCACACUGAAUACCAAUU
    TTGGTATTCAGTGTGATGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,5,7,8,9,12,14,17 * 3,4,6,10,11,13,15,16,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    93.97 percent target mRNA inhibition
    22253019
    SM5067
    UCAUCACACUGAAUACCAAUU
    UUGGUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,5,7,8,9,12,17,20,21 * 3,4,6,10,11,13,15,16,18,19 * 14
    Base; Sugar; Sugar
    Sugar
    94.94 percent target mRNA inhibition
    22253019
    SM5068
    UCAUCACACUGAAUACCAAUU
    GUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    70.58 percent target mRNA inhibition
    22253019
    SM5069
    UCAUCACACUGAAUACCAAUU
    GTATTCAGTGTGATGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1* 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    53.9 percent target mRNA inhibition
    22253019
    SM5070
    UCAUCACACUGAAUACCAAUU
    GUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    81.11 percent target mRNA inhibition
    22253019
    SM5071
    UCAUCACACUGAAUACCAAUU
    GUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,12,13,14,15,16,17,18 * 11
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    84.93 percent target mRNA inhibition
    22253019
    SM5072
    UCAUCACACUGAAUACCAAUU
    GUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,7,8,10,12,13,15,16 * 2,4,5,6,9,11,14 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    59.99 percent target mRNA inhibition
    22253019
    SM5073
    UCAUCACACUGAAUACCAAUU
    GUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,7,8,10,12,13,15,16 * 2,4,5,6,9,11,14 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    60.63 percent target mRNA inhibition
    22253019
    SM5074
    UCAUCACACUGAAUACCAAUU
    GUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Methoxy* 2-Fluoro
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,7,8,10,12,13,15,16,17,18 * 2,4,5,6,9,11,14
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    74.71 percent target mRNA inhibition
    22253019
    SM5075
    UCAUCACACUGAAUACCAAUU
    GUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,7,8,10,12,13,15,16 * 2,4,5,6,9,11,14 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    66.88 percent target mRNA inhibition
    22253019
    SM5076
    UCAUCACACUGAAUACCAAUU
    GTATTCAGTGTGATGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,7,8,10,12,13,15,16 * 2,4,5,6,9,11,14 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    58.32 percent target mRNA inhibition
    22253019
    SM5077
    UCAUCACACUGAAUACCAAUU
    GUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,7,8,10,12,13,15,16 * 2,4,5,6,9,14,17,18 * 11
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    83.22 percent target mRNA inhibition
    22253019
    SM5078
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    91.33 percent target mRNA inhibition
    22253019
    SM5079
    ACAACAGACUUUAAUGUAAUU
    TTACATTAAAGTCTGTTGTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    64.3 percent target mRNA inhibition
    22253019
    SM5080
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    90.57 percent target mRNA inhibition
    22253019
    SM5081
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    88.27 percent target mRNA inhibition
    22253019
    SM5082
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,4,6,7,12,13,14,16,17,19 * 3,5,8,9,10,11,15,18 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    91.63 percent target mRNA inhibition
    22253019