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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 22253019 are 360
    Results from 225 - 250
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM5183
    CACAAUGCAUUUAGAUCAAUU
    UUGAUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,5,6,7,11,13,15,16,18 * 3,4,8,9,10,12,14,17,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    75.25 percent target mRNA inhibition
    22253019
    SM5184
    CACAAUGCAUUUAGAUCAAUU
    UUGAUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,5,6,7,11,13,15,16,18 * 3,4,8,9,10,12,14,17,19,20,21
    Base; Sugar; Sugar
    Sugar
    73.77 percent target mRNA inhibition
    22253019
    SM5185
    CACAAUGCAUUUAGAUCAAUU
    UUGAUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,5,6,7,11,13,15,16,18 * 3,4,8,9,10,12,14,17,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    98.54 percent target mRNA inhibition
    22253019
    SM5186
    CACAAUGCAUUUAGAUCAAUU
    TTGATCTAAATGCATTGTGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,5,6,7,11,13,15,16,18 * 3,4,8,9,10,12,14,17,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    36.81 percent target mRNA inhibition
    22253019
    SM5187
    CACAAUGCAUUUAGAUCAAUU
    UUGAUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,5,6,7,11,13,15,16,18,20,21* 3,4,8,9,10,12,17,19 * 14
    Base; Sugar; Sugar
    Sugar
    96.92 percent target mRNA inhibition
    22253019
    SM5188
    CACAAUGCAUUUAGAUCAAUU
    AUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    28.67 percent target mRNA inhibition
    22253019
    SM5189
    CACAAUGCAUUUAGAUCAAUU
    ATCTAAATGCATTGTGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    14.94 percent target mRNA inhibition
    22253019
    SM5190
    CACAAUGCAUUUAGAUCAAUU
    AUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    94.42 percent target mRNA inhibition
    22253019
    SM5191
    CACAAUGCAUUUAGAUCAAUU
    AUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,12,13,14,15,16,17,18 * 11
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    23.02 percent target mRNA inhibition
    22253019
    SM5192
    CACAAUGCAUUUAGAUCAAUU
    AUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,5,6,7,9,11,14,16 * 2,3,4,8,10,12,13,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    87.3 percent target mRNA inhibition
    22253019
    SM5193
    CACAAUGCAUUUAGAUCAAUU
    AUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,5,6,7,9,11,14,16 * 2,3,4,8,10,12,13,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    78.86 percent target mRNA inhibition
    22253019
    SM5194
    CACAAUGCAUUUAGAUCAAUU
    AUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Methoxy* 2-Fluoro
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,5,6,7,9,11,14,16,17,18 * 2,3,4,8,10,12,13,15
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    42.73 percent target mRNA inhibition
    22253019
    SM5195
    CACAAUGCAUUUAGAUCAAUU
    AUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,5,6,7,9,11,14,16 * 2,3,4,8,10,12,13,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    70.83 percent target mRNA inhibition
    22253019
    SM5196
    CACAAUGCAUUUAGAUCAAUU
    ATCTAAATGCATTGTGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,5,6,7,9,11,14,16 * 2,3,4,8,10,12,13,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    37.16 percent target mRNA inhibition
    22253019
    SM5197
    CACAAUGCAUUUAGAUCAAUU
    AUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,5,6,7,9,14,16 * 2,3,4,8,10,12,13,15,17,18 * 11
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    43.98 percent target mRNA inhibition
    22253019
    SM5198
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    95.04 percent target mRNA inhibition
    22253019
    SM5199
    CUUUAACAAUUCCUGAAAUUU
    ATTTCAGGAATTGTTAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    13.91 percent target mRNA inhibition
    22253019
    SM5200
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    97.21 percent target mRNA inhibition
    22253019
    SM5201
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    92.56 percent target mRNA inhibition
    22253019
    SM5202
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,6,7,8,9,10,13,16,17,18,19 * 2,3,4,5,11,12,14,15 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    91.9 percent target mRNA inhibition
    22253019
    SM5203
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,6,7,8,9,10,13,16,17,18,19 * 2,3,4,5,11,12,14,15 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    27.13 percent target mRNA inhibition
    22253019
    SM5204
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Methoxy* 2-Fluoro
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,6,7,8,9,10,13,16,17,18,19,20,21* 2,3,4,5,11,12,14,15
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    93.72 percent target mRNA inhibition
    22253019
    SM5205
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,6,7,8,9,10,13,16,17,18,19 * 2,3,4,5,11,12,14,15 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    97.5 percent target mRNA inhibition
    22253019
    SM5206
    CUUUAACAAUUCCUGAAAUUU
    ATTTCAGGAATTGTTAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,6,7,8,9,10,13,16,17,18,19 * 2,3,4,5,11,12,14,15 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    44.02 percent target mRNA inhibition
    22253019
    SM5207
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,6,7,8,9,10,13,16,17,18,19 * 2,3,4,5,11,12,15,20,21 * 14
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    96.89 percent target mRNA inhibition
    22253019