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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 22260772 are 53
Results from 25 - 50

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM4569	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	20 20	Backbone Backbone	96 percent target mRNA inhibition	22260772
SM4570	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	15,20 20,21	Backbone Sugar	98 percent target mRNA inhibition	22260772
SM4571	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	15,20 20	Backbone Backbone	81 percent target mRNA inhibition	22260772
SM4572	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	2,15,20 20,21	Backbone Sugar	74 percent target mRNA inhibition	22260772
SM4573	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine Triazole-linked nucleic acid	20,21 20	Sugar Backbone	89 percent target mRNA inhibition	22260772
SM4574	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	98 percent target mRNA inhibition	22260772
SM4575	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	1 * 20,21 20,21	Sugar; Backbone Sugar	90 percent target mRNA inhibition	22260772
SM4576	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine Triazole-linked nucleic acid	1 * 20,21 20	Sugar; Backbone Backbone	96 percent target mRNA inhibition	22260772
SM4577	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	1,14 * 20,21 20,21	Sugar; Backbone Sugar	94 percent target mRNA inhibition	22260772
SM4578	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	2 * 20,21 20,21	Sugar; Backbone Sugar	96 percent target mRNA inhibition	22260772
SM4579	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	7 * 20,21 20,21	Sugar; Backbone Sugar	94 percent target mRNA inhibition	22260772
SM4580	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	14 * 20,21 20,21	Sugar; Backbone Sugar	96 percent target mRNA inhibition	22260772
SM4581	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine Triazole-linked nucleic acid	14 * 20,21 20	Sugar; Backbone Backbone	97 percent target mRNA inhibition	22260772
SM4582	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	15 * 20,21 20,21	Sugar; Backbone Sugar	99 percent target mRNA inhibition	22260772
SM4583	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	20 20,21	Backbone Sugar	95 percent target mRNA inhibition	22260772
SM4584	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	20 20	Backbone Backbone	96 percent target mRNA inhibition	22260772
SM4585	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	15,20 20,21	Backbone Sugar	97 percent target mRNA inhibition	22260772
SM4586	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	15,20 20	Backbone Backbone	85 percent target mRNA inhibition	22260772
SM4587	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	2,15,20 20,21	Backbone Sugar	77 percent target mRNA inhibition	22260772
SM4588	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine Triazole-linked nucleic acid	20,21 20	Sugar Backbone	98 percent target mRNA inhibition	22260772
SM4589	GGUCAUCCAUGACAACUUUTT AAAGUUGUCAUGGAUGACCTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	80 percent target mRNA inhibition	22260772
SM4590	GGUCAUCCAUGACAACUUUTT AAAGUUGUCAUGGAUGACCTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	17 * 20,21 20,21	Sugar; Backbone Sugar	86 percent target mRNA inhibition	22260772
SM4591	GGUCAUCCAUGACAACUUUTT AAAGUUGUCAUGGAUGACCTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	18 * 20,21 20,21	Sugar; Backbone Sugar	85 percent target mRNA inhibition	22260772
SM4592	GGUCAUCCAUGACAACUUUTT AAAGUUGUCAUGGAUGACCTT	Triazole-linked nucleic acid 2-Deoxythymidine	20 20,21	Sugar; Backbone Sugar	81 percent target mRNA inhibition	22260772
SM4593	GGUCAUCCAUGACAACUUUTT AAAGUUGUCAUGGAUGACCTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	94 percent target mRNA inhibition	22260772



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