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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 3,8,13,15,20,21 are 48
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM0043	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-O-Methyl	3,8,13,15,20,21 2	Sugar Sugar	16 percent target mRNA inhibition	19282453
SM0089	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid 2-O-Methyl* 2-Aminoethyl	3,8,13,15,20,21 1 * 21	Sugar Sugar	81 percent target mRNA inhibition	19282453
SM0134	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid 2-O-Methyl* 2-Cyanoethyl	3,8,13,15,20,21 1 * 18	Sugar Sugar	10.2 percent target mRNA inhibition	19282453
SM0179	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid Altritol nucleic acid	3,8,13,15,20,21 1,2	Sugar Sugar	23 percent target mRNA inhibition	19282453
SM0224	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Altritol nucleic acid	3,8,13,15,20,21 20,21	Sugar Sugar	88.1 percent target mRNA inhibition	19282453
SM0269	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Altritol nucleic acid	3,8,13,15,20,21 5,8,11,14,17,20	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0314	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Altritol nucleic acid	3,8,13,15,20,21 3,6,14,18,20,21	Sugar Sugar	24.6 percent target mRNA inhibition	19282453
SM0359	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,8,13,15,20,21 18,19,20 * 21	Sugar Sugar	83.2 percent target mRNA inhibition	19282453
SM0404	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,8,13,15,20,21 2,18,19,20 * 21	Sugar Sugar	67.6 percent target mRNA inhibition	19282453
SM0449	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,8,13,15,20,21 3,18,19,20 * 21	Sugar Sugar	73.8 percent target mRNA inhibition	19282453
SM0494	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,8,13,15,20,21 2,9,18,19,20 * 21	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0539	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid 2-Aminoethoxymethyl* 2-Deoxy	3,8,13,15,20,21 18,19 * 21	Sugar Sugar	41 percent target mRNA inhibition	19282453
SM0584	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid 2-Aminopropoxymethyl* 2-Deoxy	3,8,13,15,20,21 18,19 * 21	Sugar Sugar	27.1 percent target mRNA inhibition	19282453
SM0629	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Fluoro* 2-O-Methyl	3,8,13,15,20,21 1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20	Sugar Sugar	10.5 percent target mRNA inhibition	19282453
SM0674	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	3,8,13,15,20,21 3,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0719	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	3,8,13,15,20,21 4,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0764	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	3,8,13,15,20,21 3,4,18	Sugar Sugar	63.5 percent target mRNA inhibition	19282453
SM0809	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	3,8,13,15,20,21 3,18	Sugar Sugar	0.9 percent target mRNA inhibition	19282453
SM0854	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	3,8,13,15,20,21 4,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0899	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	3,8,13,15,20,21 3,4,18	Sugar Sugar	69 percent target mRNA inhibition	19282453
SM0944	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	3,8,13,15,20,21 3,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0989	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	3,8,13,15,20,21 4,18	Sugar Sugar	1.4 percent target mRNA inhibition	19282453
SM1034	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	3,8,13,15,20,21 3,4,18	Sugar Sugar	10.7 percent target mRNA inhibition	19282453
SM1079	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid 2-Aminoethyl	3,8,13,15,20,21 20,21	Sugar Sugar	88.3 percent target mRNA inhibition	19282453
SM1124	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid 2-Aminopropyl	3,8,13,15,20,21 1	Sugar Sugar	12.8 percent target mRNA inhibition	19282453



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