Representation of Major Biochemical Pathway categories by the genes in PCMdb


A list of genes in PCMdb that can be classified as "Negative regulators of Molecular Function" is provided below.
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Gene Symbol Gene Name # of Entries
SFNstratifin33
14-3-3?stratifin0
SH3BP5SH3-domain binding protein 5 (BTK-associated)20
SERPINA1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
A2ML1alpha-2-macroglobulin-like 140
TNK2tyrosine kinase, non-receptor, 21
ACTN2actinin, alpha 240
ADRA2Aadrenoceptor alpha 2A10
JUBajuba LIM protein1
AKT1v-akt murine thymoma viral oncogene homolog 19
AMBPalpha-1-microglobulin/bikunin precursor20
AMOTL1angiomotin9
FLIIflightless I homolog (Drosophila)0
PRMT2protein arginine methyltransferase 21
NPR3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)30
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 120
ANXA3annexin A320
ANXA4annexin A410
TFtranscription factor AP-2 beta (activating enhancer binding protein 2 beta)21
APCDD1Ladenomatous polyposis coli1
APOA1apolipoprotein A-I13
LPAlipoprotein, Lp(a)20
AQP12Aaquaporin 1 (Colton blood group)20
BAXBCL2-associated X protein13
BIRC5baculoviral IAP repeat containing 59
BMP4bone morphogenetic protein 414
BMP7bone morphogenetic protein 729
CASP3caspase 3, apoptosis-related cysteine peptidase13
C19orf29cactin, spliceosome C complex subunit1
CBLCCbl proto-oncogene, E3 ubiquitin protein ligase C40
CCDC88Ccoiled-coil domain containing 810
CCL5chemokine (C-C motif) ligand 520
CD109CD109 molecule1
CDKN2Acyclin-dependent kinase inhibitor 2A2
p16cyclin-dependent kinase inhibitor 2A1710
P16cyclin-dependent kinase inhibitor 2A56
p16INK4acyclin-dependent kinase inhibitor 2A40
p16INK4Acyclin-dependent kinase inhibitor 2A14
LY86-AS1LY86 antisense RNA 11
CD2BP2CD2 (cytoplasmic tail) binding protein 29
CD44CD44 molecule (Indian blood group)5
p21cip1cyclin-dependent kinase inhibitor 1A (p21, Cip1)2
CDKN1Ccyclin-dependent kinase inhibitor 1C (p57, Kip2)20
p15cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)104
p15INK4bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)2
CEBPGCCAAT/enhancer binding protein (C/EBP), gamma1
TERTtescalcin9
CMYA5cardiomyopathy associated 51
COL6A3collagen, type VI, alpha 320
NR2F2nuclear receptor subfamily 2, group F, member 210
CYP27B1cytochrome P450, family 27, subfamily B, polypeptide 120
CYP2D6cytochrome P450, family 2, subfamily D, polypeptide 61
CR1complement component (3b/4b) receptor 1 (Knops blood group)20
CRHcorticotropin releasing hormone binding protein20
CRIPAKcysteine-rich PAK1 inhibitor9
R3HDMLR3H domain containing-like20
CSTAcystatin A (stefin A)40
CSTBcystatin B (stefin B)9
DAPK1death-associated protein kinase 163
DAPdeath-associated protein0
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked1
DGKIdiacylglycerol kinase, iota40
DGKZdiacylglycerol kinase, zeta20
DHCR2424-dehydrocholesterol reductase13
DKK1dickkopf WNT signaling pathway inhibitor 16
DLG3discs, large homolog 3 (Drosophila)1
DNAJB6DnaJ (Hsp40) homolog, subfamily B, member 61
DRD2dopamine receptor D231
DRD4dopamine receptor D421
DRD5dopamine receptor D520
DUSP18dual specificity phosphatase 181
DUSP22dual specificity phosphatase 222
DUSP4dual specificity phosphatase 410
DUSP5dual specificity phosphatase 51
DUSP6dual specificity phosphatase 64
DUSP9dual specificity phosphatase 91
EPB41L5erythrocyte membrane protein band 4.1 like 59
EDNRBendothelin receptor type B100
PI3peptidase inhibitor 3, skin-derived13
MLLT10myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 19
EPOerythropoietin41
SPINLW1epididymal peptidase inhibitor21
ESR1estrogen receptor 1109
FABP1fatty acid binding protein 1, liver20
FGF11fibroblast growth factor 1222
FLNAfilamin A, alpha10
ZFPM1zinc finger protein, FOG family member 11
FOXA2forkhead box A210
FOXJ1forkhead box J111
FKHL18forkhead box S11
FURINfurin (paired basic amino acid cleaving enzyme)1
FZD1frizzled family receptor 1010
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)1
GADD45Agrowth arrest and DNA-damage-inducible, alpha1
GADD45Bgrowth arrest and DNA-damage-inducible, beta9
GABBR2gamma-aminobutyric acid (GABA) B receptor, 220
GALR1galanin receptor 1124
GAS6growth arrest-specific 610
GNB2L1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 11
SERPINE2serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 220
GFI1growth factor independent 1 transcription repressor10
GMFGglia maturation factor, gamma1
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 29
GNAT1guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 110
GPC3glypican 31
GRM2glutamate receptor, metabotropic 21
GRM8glutamate receptor, metabotropic 810
GSTM2glutathione S-transferase mu 2 (muscle)13
GSTP1glutathione S-transferase pi 163
GSTpglutathione S-transferase pi 130
HAND1heart and neural crest derivatives expressed 154
HAND2heart and neural crest derivatives expressed 230
HDAC4histone deacetylase 41
HEXIM2hexamethylene bis-acetamide inducible 21
HEY1hairy/enhancer-of-split related with YRPW motif 19
HEYLhairy/enhancer-of-split related with YRPW motif-like20
HGFhepatocyte growth factor (hepapoietin A; scatter factor)20
HSPBP1HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 11
HYAL2hyaluronoglucosaminidase 21
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein13
IGF1Rinsulin-like growth factor 1 receptor10
NFKBIDnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta9
IL1Binterleukin 1, beta20
IL1RNinterleukin 1 receptor antagonist33
IL7interleukin 71
INSM2insulin10
INTS1integrator complex subunit 11
IRAK1interleukin-1 receptor-associated kinase 19
IRS2insulin receptor substrate 29
SPINK2serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)20
ISL1ISL LIM homeobox 11
ITIH1inter-alpha-trypsin inhibitor heavy chain 120
ITIH3inter-alpha-trypsin inhibitor heavy chain 320
ITIH4inter-alpha-trypsin inhibitor heavy chain family, member 420
JAK2Janus kinase 21
SERPINA4serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 420
KAL1Kallmann syndrome 1 sequence1
KDM1lysine (K)-specific demethylase 1A1
PRKCAprotein kinase C, alpha10
PRKCZprotein kinase C, zeta1
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 31
LCN15lipocalin 19
LHX2LIM homeobox 241
LIMK1LIM domain kinase 11
LMTK2lemur tyrosine kinase 213
LRP5low density lipoprotein receptor-related protein 51
ZFYVE28zinc finger, FYVE domain containing 281
MAP3K1mitogen-activated protein kinase kinase kinase 101
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)1
MDFICMyoD family inhibitor1
MDM2MDM2 oncogene, E3 ubiquitin protein ligase9
MEN1multiple endocrine neoplasia I24
MSX1msh homeobox 1129
MSX2msh homeobox 21
MT3metallothionein 320
MYO1Dmyosin ID1
CIAS1NLR family, pyrin domain containing 31
NESnestin23
PDZD3PDZ domain containing 320
CARD15nucleotide-binding oligomerization domain containing 213
NOS1nitric oxide synthase 1 (neuronal)21
NOS3nitric oxide synthase 3 (endothelial cell)34
NOTCH1notch 11
NQO1NAD(P)H dehydrogenase, quinone 113
NR0B1nuclear receptor subfamily 0, group B, member 11
OAZ1ornithine decarboxylase antizyme 11
OPRM1opioid receptor, mu 140
OXA1Loxidase (cytochrome c) assembly 1-like1
TP53tumor protein p531
TP73tumor protein p73100
p73tumor protein p7388
P73tumor protein p7356
ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary)43
PALM2paralemmin1
PAX2paired box 210
PCSK1Nproprotein convertase subtilisin/kexin type 1 inhibitor1
PDPK13-phosphoinositide dependent protein kinase-120
PELI1pellino E3 ubiquitin protein ligase 11
PHACTR1phosphatase and actin regulator 110
PHACTR2phosphatase and actin regulator 220
PHACTR3phosphatase and actin regulator 321
PIF1PIF1 5'-to-3' DNA helicase1
PKMYT1protein kinase, membrane associated tyrosine/threonine 11
PPP1R14Bprotein phosphatase 1, regulatory (inhibitor) subunit 14B1
PPP1R14Cprotein phosphatase 1, regulatory (inhibitor) subunit 14C1
PPARGC1Bperoxisome proliferator-activated receptor gamma1
PPM1Eprotein phosphatase, Mg2+/Mn2+ dependent, 1E30
PPM1Fprotein phosphatase, Mg2+/Mn2+ dependent, 1F1
PPP1R1Bprotein phosphatase 1, regulatory (inhibitor) subunit 1B9
KIAA0649protein phosphatase 1, regulatory subunit 261
ELFN2extracellular leucine-rich repeat and fibronectin type III domain containing 21
C14orf50protein phosphatase 1, regulatory subunit 369
PRDX5peroxiredoxin 59
PSMC1proteasome (prosome, macropain) 26S subunit, ATPase, 11
PSMC3proteasome (prosome, macropain) 26S subunit, ATPase, 31
PSMA1proteasome (prosome, macropain) subunit, alpha type, 19
PSMA3proteasome (prosome, macropain) subunit, alpha type, 31
PSMA7proteasome (prosome, macropain) subunit, alpha type, 71
PSMD5proteasome (prosome, macropain) 26S subunit, non-ATPase, 520
PSMD8proteasome (prosome, macropain) 26S subunit, non-ATPase, 89
PTCH1patched 11
PTENphosphatase and tensin homolog9
PTGISprostaglandin I2 (prostacyclin) synthase30
PTHLHparathyroid hormone-like hormone63
PTK6protein tyrosine kinase 633
PTPN6protein tyrosine phosphatase, non-receptor type 613
PTPRNprotein tyrosine phosphatase, receptor type, N polypeptide 241
PTPRJprotein tyrosine phosphatase, receptor type, J20
PXDNperoxidasin homolog (Drosophila)50
PYDC1PYD (pyrin domain) containing 111
RECKreversion-inducing-cysteine-rich protein with kazal motifs30
RIMBP2RIMS binding protein 21
RNH1ribonuclease/angiogenin inhibitor 11
UBA52ubiquitin A-52 residue ribosomal protein fusion product 11
SEMA4Dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D1
SFRP1secreted frizzled-related protein 1105
SARP2secreted frizzled-related protein 1235
SFRP2secreted frizzled-related protein 271
SFRP4secreted frizzled-related protein 43
SFRP5secreted frizzled-related protein 52
SIGIRRsingle immunoglobulin and toll-interleukin 1 receptor (TIR) domain1
SIN3ASIN3 transcription regulator homolog A (yeast)1
SKIv-ski sarcoma viral oncogene homolog (avian)1
SLIT2slit homolog 2 (Drosophila)64
SMOC2smoothened, frizzled family receptor50
SOCS1suppressor of cytokine signaling 1233
SRIsorcin20
SOX10SRY (sex determining region Y)-box 111
SERPINB13serpin peptidase inhibitor, clade B (ovalbumin), member 1320
SERPINB5serpin peptidase inhibitor, clade B (ovalbumin), member 5109
Maspinserpin peptidase inhibitor, clade B (ovalbumin), member 544
SPRED2sprouty-related, EVH1 domain containing 21
SPRED3sprouty-related, EVH1 domain containing 310
SRCSRC kinase signaling inhibitor 133
SRCIN1v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1
SSPOSCO-spondin homolog (Bos taurus)10
STK38serine/threonine kinase 3820
SNCAIPsynuclein, alpha (non A4 component of amyloid precursor)41
SNCBsynuclein, beta31
TMEM132Dtransmembrane protein 132D10
KIAA1944transmembrane protein 132D1
TESCtestis expressed 1410
TCF7L1transcription factor 7-like 2 (T-cell specific, HMG-box)1
TFAP2Ctranscription factor AP-4 (activating enhancer binding protein 4)30
TNFAIP8tumor necrosis factor, alpha-induced protein 821
TFIP11tissue factor pathway inhibitor 21
TFPI-2tissue factor pathway inhibitor 247
TGFB1transforming growth factor, beta 21
THPOThy-1 cell surface antigen20
SPOCK1sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 110
SPOCKsparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 11
TIMM9TIMP metallopeptidase inhibitor 31
TIMP3TIMP metallopeptidase inhibitor 4256
TLL2toll-like receptor 99
TAL1TAR (HIV-1) RNA binding protein 214
TRIM37tripartite motif containing 379
TRIB2tribbles homolog 2 (Drosophila)10
THthrombospondin 110
TWIST1twist basic helix-loop-helix transcription factor 1144
UBE2E1ubiquitin-conjugating enzyme E2E 11
USP44ubiquitin specific peptidase 4410
USP7ubiquitin specific peptidase 7 (herpes virus-associated)1
UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)121
UCNurocortin50
UGT1A1UDP glucuronosyltransferase 1 family, polypeptide A113
SCGB1A1secretoglobin, family 1A, member 1 (uteroglobin)1
VTNvitronectin20
WFDC1WAP four-disulfide core domain 10B10
WFDC10BWAP four-disulfide core domain 1220
WFDC12WAP four-disulfide core domain 1320
WFDC13WAP four-disulfide core domain 120
WFDC5WAP four-disulfide core domain 520
WFDC6WAP four-disulfide core domain 620
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 21
WNT9Awingless-type MMTV integration site family, member 9A9
WWTR1WW domain containing transcription regulator 11
XIAPX-linked inhibitor of apoptosis10
ZNF462zinc finger protein 4629
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