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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 1 are 89
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM2194	GCAGCACGACUUCUUCAAGUU CUUGAAGAAGUCGUGCUGCUU	Locked nucleic acid 0	1 0	Sugar 0	73.23 percent target mRNA inhibition	18575806
SM2195	GCAGCACGACUUCUUCAAGUU CUUGAAGAAGUCGUGCUGCUU	Locked nucleic acid 2-O-Methyl	1 2	Sugar Sugar	68.59 percent target mRNA inhibition	18575806
SM2196	GCAGCACGACUUCUUCAAGUU CUUGAAGAAGUCGUGCUGCUU	Locked nucleic acid 2-Fluoro	1 2	Sugar Sugar	69.33 percent target mRNA inhibition	18575806
SM2201	UAGUUCUGUGGGGCUGUUUUU AAACAGCCCCACAGAACUAUU	Locked nucleic acid 2-Fluoro	1 2	Sugar Sugar	NA	18575806
SM2207	GGCCUUUCACUACUCCUACGA GUAGGAGUAGUGAAAGGCCAG	5-Amino 0	1 0	Sugar 0	79 percent target mRNA inhibition	17894530
SM2209	CUGGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG	5-Amino 5-Amino	1 1	Sugar Sugar	83 percent target mRNA inhibition	17894530
SM2211	CUGGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG	5-Amino 0	1 0	Sugar 0	97 percent target mRNA inhibition	17894530
SM2215	CUGGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG	5-Amino 3-Amino	1 27	Sugar Sugar	89 percent target mRNA inhibition	17894530
SM2218	CUGGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG	5-Amino 5-Amino	1 27	Sugar Sugar	51 percent target mRNA inhibition	17894530
SM2220	CUGGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG	5-Amino 0	1 0	Sugar 0	76 percent target mRNA inhibition	17894530
SM2224	CUGGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG	5-Amino 3-Amino	1 27	Sugar Sugar	70 percent target mRNA inhibition	17894530
SM2226	CUGGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG	5-Thio 5-Thio	1 1	Sugar Sugar	81 percent target mRNA inhibition	17894530
SM2228	CUGGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG	5-Thio 0	1 0	Sugar 0	94 percent target mRNA inhibition	17894530
SM2229	CUGGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG	5-Cholesterol 0	1 0	Sugar 0	70 percent target mRNA inhibition	17894530
SM2230	CUGGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG	5-Cholesterol 5-Amino	1 1	Sugar Sugar	56 percent target mRNA inhibition	17894530
SM2231	CUGGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG	5-Cholesterol 3-Amino	1 1	Sugar Sugar	49 percent target mRNA inhibition	17894530
SM2232	CUGGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG	5-Thio 5-Thio	1 1	Sugar Sugar	68 percent target mRNA inhibition	17894530
SM2234	CUGGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG	5-Thio 0	1 0	Sugar 0	80 percent target mRNA inhibition	17894530
SM2236	GGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG	5-Amino 0	1 0	Sugar 0	86 percent target mRNA inhibition	17894530
SM2238	GGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG	5-Amino 0	1 0	Sugar 0	63 percent target mRNA inhibition	17894530
SM2344	AUCUGAAGAAGGAGAAAAATT UUUUUCUCCUUCUUCAGAUTT	2-Hydroxyethyl 2,3,4,6-tetra-O-Methyl-b-D-Glucopyranoside 0	1 0	Phosphate 0	91 percent target mRNA inhibition	23764303
SM2345	AUCUGAAGAAGGAGAAAAATT UUUUUCUCCUUCUUCAGAUTT	12-Hydroxydodecyl 2,3,4,6-Tetra-O-Methyl-b-D-Glucopyranoside 0	1 0	Phosphate 0	89 percent target mRNA inhibition	23764303
SM2346	AUCUGAAGAAGGAGAAAAATT UUUUUCUCCUUCUUCAGAUTT	12-[(2,3,4,6-Tetra-O-methyl-b-D-glucopyranosyloxy)]dodecyl (2-cyanoethyl) (N,N-diisopropyl) phosphoramidite derivative 0	1 0	Phosphate 0	79 percent target mRNA inhibition	23764303
SM2347	AUCUGAAGAAGGAGAAAAATT UUUUUCUCCUUCUUCAGAUTT	Dodecyl derivative 0	1 0	Phosphate 0	78 percent target mRNA inhibition	23764303
SM2479	GGCCUUUCACUACUCCUACGA GUAGGAGUAGUGAAAGGCCAG	Phenyl 0	1 0	Phosphate 0	92 percent target mRNA inhibition	22982308



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