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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 1 * 21,22 are 4
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4432
    GGCCUUUCACUACUCCUACTT
    GUAGGAGUAGUGAAAGGCCTT
    Fluorescein* 2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    1 * 21,22
    20,21
    Base
    Base
    NA
    21141919
    SM4433
    GGCCUUUCACUACUCCUACTT
    GUAGGAGUAGUGAAAGGCCTT
    Fluorescein* [1,1-Biphenyl]-3,5-dimethanol
    [1,1-Biphenyl]-3,5-dimethanol
    1 * 21,22
    21,22
    Base
    Base
    NA
    21141919
    SM4444
    UAAGAUGUUCAUCGAGUCCTT
    GGACUCGAUGAACAUCUUATT
    [3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* [3-(hydroxymethyl)phenyl]methanol
    [3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* 1,3-Benzenedimethanol
    1 * 21,22
    20 * 21
    Base
    Base
    58 percent target mRNA inhibition
    21141919
    SM4445
    UAAGAUGUUCAUCGAGUCCTT
    GGACUCGAUGAACAUCUUATT
    [3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* [3-(hydroxymethyl)phenyl]methanol
    [3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol
    1 * 21,22
    21,22
    Base
    Base
    71 percent target mRNA inhibition
    21141919