Browse By

Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 21 are 161
Results from 75 - 100

« previous1234567next »

SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM1704	GACGUAAACGGCCACAAGUUTU ACUUGTGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid 2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid	21 6 * 20,21	Sugar Sugar	70.2 percent target mRNA inhibition	19282453
SM1708	GACGUAAACGGCCACAAGUUUU ACUUGTGGCCGUUUACGUCGCU	UnLocked nucleic acid 2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid	21 6 * 20,21	Sugar Sugar	69.9 percent target mRNA inhibition	19282453
SM1749	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGTCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid 2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid	21 18 * 20,21	Sugar Sugar	61.3 percent target mRNA inhibition	19282453
SM1753	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGTCGCU	UnLocked nucleic acid 2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid	21 18 * 20,21	Sugar Sugar	67.3 percent target mRNA inhibition	19282453
SM1794	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid 2-O-Methyl	21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22	Sugar Sugar	6.1 percent target mRNA inhibition	19282453
SM1798	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid 2-O-Methyl	21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22	Sugar Sugar	13 percent target mRNA inhibition	19282453
SM1839	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Unlocked nucleic acid* Locked nucleic acid	21 6 * 20,21	Sugar Sugar	89.6 percent target mRNA inhibition	19282453
SM1843	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Unlocked nucleic acid* Locked nucleic acid	21 6 * 20,21	Sugar Sugar	93.8 percent target mRNA inhibition	19282453
SM1884	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Unlocked nucleic acid* Locked nucleic acid	21 3 * 20,21	Sugar Sugar	81.2 percent target mRNA inhibition	19282453
SM1888	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Unlocked nucleic acid* Locked nucleic acid	21 3 * 20,21	Sugar Sugar	88.5 percent target mRNA inhibition	19282453
SM1929	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Unlocked nucleic acid* Locked nucleic acid	21 18 * 20,21	Sugar Sugar	89.2 percent target mRNA inhibition	19282453
SM1933	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Unlocked nucleic acid* Locked nucleic acid	21 18 * 20,21	Sugar Sugar	89.3 percent target mRNA inhibition	19282453
SM1974	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Unlocked nucleic acid* Locked nucleic acid	21 12 * 20,21	Sugar Sugar	86.3 percent target mRNA inhibition	19282453
SM1978	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Unlocked nucleic acid* Locked nucleic acid	21 12 * 20,21	Sugar Sugar	87.9 percent target mRNA inhibition	19282453
SM2019	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Unlocked nucleic acid	21 21	Sugar Sugar	79.4 percent target mRNA inhibition	19282453
SM2023	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Unlocked nucleic acid	21 21	Sugar Sugar	78.9 percent target mRNA inhibition	19282453
SM2064	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Unlocked nucleic acid	21 3,21	Sugar Sugar	48.6 percent target mRNA inhibition	19282453
SM2068	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Unlocked nucleic acid	21 3,21	Sugar Sugar	53.3 percent target mRNA inhibition	19282453
SM2109	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Locked nucleic acid	21 20,21	Sugar Sugar	85 percent target mRNA inhibition	19282453
SM2113	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Locked nucleic acid	21 20,21	Sugar Sugar	83.6 percent target mRNA inhibition	19282453
SM2154	GACGUAAACGGCCACAAGUUTU ACTUGTGGCCGUUTACGTCGC	4-C-Hydroxymethyl Deoxyribonucleic acid Locked nucleic acid	21 3,6,14,18,20,21	Sugar Sugar	11.9 percent target mRNA inhibition	19282453
SM2158	GACGUAAACGGCCACAAGUUUU ACTUGTGGCCGUUTACGTCGC	UnLocked nucleic acid Locked nucleic acid	21 3,6,14,18,20,21	Sugar Sugar	12.7 percent target mRNA inhibition	19282453
SM2373	CUUCUUCGUCGAGACCAUGTX CAUGGUCUCGACGAAGAAGTX	Thymidine analogue Thymidine analogue	21 21	Base Base	15 percent target mRNA inhibition	23743279
SM2374	CUUCUUCGUCGAGACCAUGTY CAUGGUCUCGACGAAGAAGTY	Glucosamine analogue Glucosamine analogue	21 21	Base Base	13 percent target mRNA inhibition	23743279
SM2380	CUUCUUCGUCGAGACCAUGTX CAUGGUCUCGACGAAGAAGTX	Thymidine analogue Thymidine analogue	21 21	Base Base	34 percent target mRNA inhibition	23743279



« previous1234567next »