SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM2412 |
AATCAGACAAGUUCUUCAUTT AUGAAGAACUUGUCUGAUUTT |
Boron cluster 0 |
3 0 |
Base 0 |
97 percent target mRNA inhibition | 23682800 |
SM2415 |
AAUCAGACAAGUUCUUCAUTT AUGAAGAACUUGUCUGAUUTT |
Boron cluster Boron cluster |
3 20 |
Base Base |
97 percent target mRNA inhibition | 23682800 |
SM2418 |
AATCAGACAAGUUCUUCAUTT AUGAAGAACUUGUCUGAUUTT |
Boron cluster 0 |
3 0 |
Base 0 |
83 percent target mRNA inhibition | 23682800 |
SM2421 |
AAUCAGACAAGUUCUUCAUTT AUGAAGAACUUGUCUGAUUTT |
Boron cluster Boron cluster |
3 20 |
Base Base |
78 percent target mRNA inhibition | 23682800 |
SM2653 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
Morpholinouridine 0 |
3 0 |
Sugar 0 |
85 percent target mRNA inhibition | 19233658 |
SM3550 |
AAUAAGCAGCUCGCGCUCCTT GGAGCGCGAGCUGCUUAUUTT |
2-O-Methyl 2-O-Methyl |
3 16 |
Sugar Sugar |
69 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3562 |
CUAGAGGAUCUUGAAGACCTT GGUCUUCAAGAUCCUCUAGTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
3 17 |
Sugar Sugar |
82 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3570 |
GAUAGGAAGGGGCUUCAGCTT GCUGAAGCCCCUUCCUAUCTT |
2-O-Methyl 2-O-Methyl |
3 16,17 |
Sugar Sugar |
41 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3586 |
GAUACUUCUGGUUCCCUCCTT GGAGGGAACCAGAAGUAUCTT |
2-O-Methyl 2-O-Methyl |
3 16 |
Sugar Sugar |
46 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3610 |
GGUAGAAUAGGUUUUCCCCTT GGGGAAAACCUAUUCUACCTT |
2-O-Methyl 2-O-Methyl |
3 11 |
Sugar Sugar |
82 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3742 |
UCUACACCGCGCCCCCCUCTT GAGGGGGGCGCGGUGUAGATT |
2-O-Methyl 2-O-Methyl |
3 16 |
Sugar Sugar |
79 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3750 |
GCUACCGCAACCACGAGCUTT AGCUCGUGGUUGCGGUAGCTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
3 16 |
Sugar Sugar |
45 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3786 |
AGUAAUCCGGACUCAACUCTT GAGUUGAGUCCGGAUUACUTT |
2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro |
3 16 |
Sugar Sugar |
69 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM4118 |
AUACUUGGCGGGCUCUUUCTT GAAAGAGCCCGCCAAGUAUTT |
2-O-Methyl 2-O-Methyl |
3 13 |
Sugar Sugar |
72 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |