SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM4878 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,2 0 |
Sugar 0 |
95.5 percent target mRNA inhibition | 17150641 |
SM4879 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,2,3,4 0 |
Sugar 0 |
94.2 percent target mRNA inhibition | 17150641 |
SM4880 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,2,3,4,16,17,18,19 0 |
Sugar 0 |
94.7 percent target mRNA inhibition | 17150641 |
SM4881 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
0 4-Thioribose |
0 18,19 |
0 Sugar |
90.2 percent target mRNA inhibition | 17150641 |
SM4882 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
0 4-Thioribose |
0 16,17,18,19 |
0 Sugar |
85.6 percent target mRNA inhibition | 17150641 |
SM4883 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 4-Thioribose |
1,2 18,19 |
Sugar Sugar |
91.3 percent target mRNA inhibition | 17150641 |
SM4884 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 4-Thioribose |
1,2,3,4 16,17,18,19 |
Sugar Sugar |
86.1 percent target mRNA inhibition | 17150641 |
SM4886 |
AAACAUGCAGAAAAUGCUGTT CAGCAUUUUCUGCAUGUUUTT |
4-Thioribose 0 |
1,2 0 |
Sugar 0 |
69.5 percent target mRNA inhibition | 17150641 |
SM4887 |
AAACAUGCAGAAAAUGCUGTT CAGCAUUUUCUGCAUGUUUTT |
4-Thioribose 0 |
1,2,3,4 0 |
Sugar 0 |
70.4 percent target mRNA inhibition | 17150641 |
SM4888 |
AAACAUGCAGAAAAUGCUGTT CAGCAUUUUCUGCAUGUUUTT |
4-Thioribose 0 |
1,2,3,4,16,17,18,19 0 |
Sugar 0 |
79.1 percent target mRNA inhibition | 17150641 |
SM4889 |
AAACAUGCAGAAAAUGCUGTT CAGCAUUUUCUGCAUGUUUTT |
0 4-Thioribose |
0 18,19 |
0 Sugar |
57.2 percent target mRNA inhibition | 17150641 |
SM4890 |
AAACAUGCAGAAAAUGCUGTT CAGCAUUUUCUGCAUGUUUTT |
0 4-Thioribose |
0 16,17,18,19 |
0 Sugar |
52.7 percent target mRNA inhibition | 17150641 |
SM4891 |
AAACAUGCAGAAAAUGCUGTT CAGCAUUUUCUGCAUGUUUTT |
4-Thioribose 4-Thioribose |
1,2 18,19 |
Sugar Sugar |
72.4 percent target mRNA inhibition | 17150641 |
SM4892 |
AAACAUGCAGAAAAUGCUGTT CAGCAUUUUCUGCAUGUUUTT |
4-Thioribose 4-Thioribose |
1,2,3,4 16,17,18,19 |
Sugar Sugar |
80.7 percent target mRNA inhibition | 17150641 |