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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 18637735 are 75
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM3131
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    0
    2-O-Methyl
    0
    9,11,13,15,17,19,21,23,25,26,27
    0
    Sugar
    95 percent target mRNA inhibition
    18637735
    SM3132
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    9,11,13,15,17,19,21,23,25
    Sugar
    Sugar
    80 percent target mRNA inhibition
    18637735
    SM3133
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    0
    2-O-Methyl
    0
    7,9,11,13,15,17,19,21,23,25
    0
    Sugar
    92 percent target mRNA inhibition
    18637735
    SM3134
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    7,9,11,13,15,17,19,21,23,25
    Sugar
    Sugar
    83 percent target mRNA inhibition
    18637735
    SM3135
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    91 percent target mRNA inhibition
    18637735
    SM3136
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    0
    1,3,6,7,8,9,12,13,15,16,17,18
    0
    Sugar
    0
    92 percent target mRNA inhibition
    18637735
    SM3137
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    0
    2-O-Methyl
    0
    12,15,16,21,22,24
    0
    Sugar
    88 percent target mRNA inhibition
    18637735
    SM3138
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-O-Methyl
    1,3,6,7,8,9,12,13,15,16,17,18
    12,15,16,21,22,24
    Sugar
    Sugar
    67 percent target mRNA inhibition
    18637735
    SM3139
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    0
    2,4,5,10,11,14,19,20
    0
    Sugar
    0
    88 percent target mRNA inhibition
    18637735
    SM3140
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    0
    2-Fluoro
    0
    8,9,10,11,13,14,17,18,19,20,23,25,26
    0
    Sugar
    85 percent target mRNA inhibition
    18637735
    SM3141
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-Fluoro
    2,4,5,10,11,14,19,20
    8,9,10,11,13,14,17,18,19,20,23,25,26
    Sugar
    Sugar
    85 percent target mRNA inhibition
    18637735
    SM3142
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-O-Methyl
    2,4,5,10,11,14,19,20
    12,15,16,21,22,24
    Sugar
    Sugar
    81 percent target mRNA inhibition
    18637735
    SM3143
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-Fluoro
    1,3,6,7,8,9,12,13,15,16,17,18
    8,9,10,11,13,14,17,18,19,20,23,25,26
    Sugar
    Sugar
    14 percent target mRNA inhibition
    18637735
    SM3144
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    0
    2-Fluoro* 2-O-Methyl
    0
    8,9,10,11,13,14,17,18,19,20,23,25,26 * 12,15,16,21,22,24
    0
    Sugar
    79 percent target mRNA inhibition
    18637735
    SM3145
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-Fluoro* 2-O-Methyl
    1,3,6,7,8,9,12,13,15,16,17,18
    8,9,10,11,13,14,17,18,19,20,23,25,26 * 12,15,16,21,22,24
    Sugar
    Sugar
    3 percent target mRNA inhibition
    18637735
    SM3146
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-Fluoro* 2-O-Methyl
    2,4,5,10,11,14,19,20
    8,9,10,11,13,14,17,18,19,20,23,25,26 * 12,15,16,21,22,24
    Sugar
    Sugar
    65 percent target mRNA inhibition
    18637735
    SM3149
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    0
    2-O-Methyl
    0
    9,11,13,15,17,19,21,23,25,26,27
    0
    Sugar
    91 percent target mRNA inhibition
    18637735
    SM3150
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    9,11,13,15,17,19,21,23,25
    Sugar
    Sugar
    80 percent target mRNA inhibition
    18637735
    SM3151
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    0
    2-O-Methyl
    0
    7,9,11,13,15,17,19,21,23,25
    0
    Sugar
    89 percent target mRNA inhibition
    18637735
    SM3152
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    7,9,11,13,15,17,19,21,23,25
    Sugar
    Sugar
    76 percent target mRNA inhibition
    18637735
    SM3153
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    95 percent target mRNA inhibition
    18637735
    SM3154
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    0
    1,3,6,7,8,9,12,13,15,16,17,18
    0
    Sugar
    0
    85 percent target mRNA inhibition
    18637735
    SM3155
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    0
    2-O-Methyl
    0
    12,15,16,21,22,24
    0
    Sugar
    90 percent target mRNA inhibition
    18637735
    SM3156
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-O-Methyl
    1,3,6,7,8,9,12,13,15,16,17,18
    12,15,16,21,22,24
    Sugar
    Sugar
    64 percent target mRNA inhibition
    18637735
    SM3157
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    0
    2,4,5,10,11,14,19,20
    0
    Sugar
    0
    90 percent target mRNA inhibition
    18637735