SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM2645 |
CUUACGCUGAGUACUUCGAUU UCGAAGUACUCAGCGUAAGTT |
Morpholinouridine 0 |
20,21 0 |
Sugar 0 |
86 percent target mRNA inhibition | 19233658 |
SM2646 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGUU |
0 Morpholinouridine |
0 20,21 |
0 Sugar |
90 percent target mRNA inhibition | 19233658 |
SM2647 |
CUUACGCUGAGUACUUCGAUU UCGAAGUACUCAGCGUAAGUU |
Morpholinouridine Morpholinouridine |
20,21 20,21 |
Sugar Sugar |
91 percent target mRNA inhibition | 19233658 |
SM2648 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
0 Morpholinouridine |
0 1 |
0 Sugar |
8 percent target mRNA inhibition | 19233658 |
SM2649 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
0 Morpholinouridine |
0 7 |
0 Sugar |
67 percent target mRNA inhibition | 19233658 |
SM2650 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
0 Morpholinouridine |
0 10 |
0 Sugar |
13 percent target mRNA inhibition | 19233658 |
SM2651 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
0 Morpholinouridine |
0 16 |
0 Sugar |
77 percent target mRNA inhibition | 19233658 |
SM2652 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
Morpholinouridine 0 |
2 0 |
Sugar 0 |
88 percent target mRNA inhibition | 19233658 |
SM2653 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
Morpholinouridine 0 |
3 0 |
Sugar 0 |
85 percent target mRNA inhibition | 19233658 |
SM2654 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
Morpholinouridine 0 |
8 0 |
Sugar 0 |
84 percent target mRNA inhibition | 19233658 |
SM2655 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
Morpholinouridine 0 |
12 0 |
Sugar 0 |
82 percent target mRNA inhibition | 19233658 |
SM2656 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
Morpholinouridine 0 |
15 0 |
Sugar 0 |
88 percent target mRNA inhibition | 19233658 |
SM2657 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
Morpholinouridine 0 |
16 0 |
Sugar 0 |
85 percent target mRNA inhibition | 19233658 |