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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 20005874 are 24
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM2677	CUAAGGACCUAACAAAGUUUU AACUUUGUUAGGUCCUUAGUU	UnLocked nucleic acid Unlocked nucleic acid* Locked nucleic acid	20 6 * 20,21	Sugar Sugar	8 percent target mRNA inhibition	20005874
SM2678	CUAAGGACCUAACAAAGUUUU AACUUUGUUAGGUCCUUAGUU	Locked nucleic acid 0	1 0	Sugar 0	64 percent target mRNA inhibition	20005874
SM2679	CUAAGGACCUAACAAAGUUUU AACUUUGUUAGGUCCUUAGUU	Locked nucleic acid* UnLocked nucleic acid 0	1 * 19 0	Sugar 0	74 percent target mRNA inhibition	20005874
SM2680	CUAAGGACCUAACAAAGUUUU AACUUUGUUAGGUCCUUAGUU	Locked nucleic acid* UnLocked nucleic acid 0	1 * 16,18,19 0	Sugar 0	70 percent target mRNA inhibition	20005874
SM2681	CUAAGGACCUAACAAAGUUUU AACUUUGUUAGGUCCUUAGUU	UnLocked nucleic acid 0	19 0	Sugar 0	60 percent target mRNA inhibition	20005874
SM2682	CUAAGGACCUAACAAAGUUUU AACUUUGUUAGGUCCUUAGUU	UnLocked nucleic acid 0	16,18,19 0	Sugar 0	70 percent target mRNA inhibition	20005874
SM2688	UUCUCCGAACGUGUCACGUUUU ACGUGACACGUUCGGAGAAUUU	UnLocked nucleic acid Unlocked nucleic acid* Locked nucleic acid	21 6 * 20,21	Sugar Sugar	2.75 (log-10 CVB-3 titre pfu/ml)	20005874
SM2689	UUCUCCGAACGUGUCACGUUUU ACGUGACACGUUCGGAGAAUUU	UnLocked nucleic acid Unlocked nucleic acid* Locked nucleic acid	21 7 * 20,21	Sugar Sugar	2.625 (log-10 CVB-3 titre pfu/ml)	20005874
SM2690	UUCUCCGAACGUGUCACGUUUU ACGUGACACGUUCGGAGAAUUU	UnLocked nucleic acid Locked nucleic acid	21 20,21	Sugar Sugar	2.93 (log-10 CVB-3 titre pfu/ml)	20005874
SM2691	UUCUCCGAACGUGUCACGUUUU ACGUGACACGUUCGGAGAAUUU	0 Unlocked nucleic acid* Locked nucleic acid	0 6 * 20,21	0 Sugar	2.73 (log-10 CVB-3 titre pfu/ml)	20005874
SM2692	UUCUCCGAACGUGUCACGUUUU ACGUGACACGUUCGGAGAAUUU	0 Unlocked nucleic acid* Locked nucleic acid	0 7 * 20,21	0 Sugar	2.5 (log-10 CVB-3 titre pfu/ml)	20005874
SM2693	UUCUCCGAACGUGUCACGUUUU ACGUGACACGUUCGGAGAAUUU	0 Locked nucleic acid	0 20,21	0 Sugar	2.93 (log-10 CVB-3 titre pfu/ml)	20005874
SM2694	UUCUCCGAACGUGUCACGUUUU ACGUGACACGUUCGGAGAAUUU	UnLocked nucleic acid 0	21 0	Sugar 0	2.73 (log-10 CVB-3 titre pfu/ml)	20005874
SM2695	UUCUCCGAACGUGUCACGUUU ACGUGACACGUUCGGAGAAUUU	UnLocked nucleic acid Unlocked nucleic acid* Locked nucleic acid	20 6 * 20,21	Sugar Sugar	2.625 (log-10 CVB-3 titre pfu/ml)	20005874
SM2696	UUCUCCGAACGUGUCACGUUU ACGUGACACGUUCGGAGAAUUU	UnLocked nucleic acid Unlocked nucleic acid* Locked nucleic acid	20 7 * 20,21	Sugar Sugar	2.75 (log-10 CVB-3 titre pfu/ml)	20005874
SM2697	UUCUCCGAACGUGUCACGUUU ACGUGACACGUUCGGAGAAUUU	UnLocked nucleic acid Locked nucleic acid	20 20,21	Sugar Sugar	2.73 (log-10 CVB-3 titre pfu/ml)	20005874
SM2698	UUCUCCGAACGUGUCACGUUU ACGUGACACGUUCGGAGAAUUU	0 Unlocked nucleic acid* Locked nucleic acid	0 6 * 20,21	0 Sugar	2.26 (log-10 CVB-3 titre pfu/ml)	20005874
SM2699	UUCUCCGAACGUGUCACGUUU ACGUGACACGUUCGGAGAAUUU	0 Unlocked nucleic acid* Locked nucleic acid	0 7 * 20,22	0 Sugar	2.78 (log-10 CVB-3 titre pfu/ml)	20005874
SM2700	UUCUCCGAACGUGUCACGUUU ACGUGACACGUUCGGAGAAUUU	0 Locked nucleic acid	0 20,21	0 Sugar	2.8 (log-10 CVB-3 titre pfu/ml)	20005874
SM2701	UUCUCCGAACGUGUCACGUUUU ACGUGACACGUUCGGAGAAUUU	UnLocked nucleic acid Unlocked nucleic acid* Locked nucleic acid	17,21 6 * 20,21	Sugar Sugar	2.87 (log-10 CVB-3 titre pfu/ml)	20005874
SM2702	UUCUCCGAACGUGUCACGUUUU ACGUGACACGUUCGGAGAAUUU	UnLocked nucleic acid Unlocked nucleic acid* Locked nucleic acid	17,21 7 * 20,21	Sugar Sugar	2.9 (log-10 CVB-3 titre pfu/ml)	20005874
SM2703	UUCUCCGAACGUGUCACGUUUU ACGUGACACGUUCGGAGAAUUU	UnLocked nucleic acid Locked nucleic acid	17,21 20,21	Sugar Sugar	2.55 (log-10 CVB-3 titre pfu/ml)	20005874
SM2704	UUCUCCGAACGUGUCACGUUUU ACGUGACACGUUCGGAGAAUUU	UnLocked nucleic acid 0	17,21 0	Sugar 0	2.56 (log-10 CVB-3 titre pfu/ml)	20005874
SM2705	UUCUCCGAACGUGUCACGUUUU ACGUGACACGUUCGGAGAAUU	UnLocked nucleic acid 0	20 0	Sugar 0	2.75 (log-10 CVB-3 titre pfu/ml)	20005874