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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
  • Total number of Results for 21047800 are 14
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4814
    GGACAUUCAGAACAAGAAATT
    UUUCUUGUUCUGAAUGUCCTT
    Thymidine
    Thymidine
    20,21
    20,21
    Sugar
    Sugar
    80 percent target mRNA inhibition
    21047800
    SM4815
    GGACAUUCAGAACAAGAAAUU
    UUUCUUGUUCUGAAUGUCCUU
    unlocked nucleic acid
    unlocked nucleic acid
    20,21
    1,20,21
    Sugar
    Sugar
    75 percent target mRNA inhibition
    21047800
    SM4816
    GGACAUUCAGAACAAGAAAUU
    UUUCUUGUUCUGAAUGUCCUU
    unlocked nucleic acid
    unlocked nucleic acid
    20,21
    2,20,21
    Sugar
    Sugar
    36 percent target mRNA inhibition
    21047800
    SM4817
    GGACAUUCAGAACAAGAAAUU
    UUUCUUGUUCUGAAUGUCCUU
    unlocked nucleic acid
    unlocked nucleic acid
    20,21
    3,20,21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    21047800
    SM4818
    GGACAUUCAGAACAAGAAAUU
    UUUCUUGUUCUGAAUGUCCUU
    unlocked nucleic acid
    unlocked nucleic acid
    20,21
    4,20,21
    Sugar
    Sugar
    50 percent target mRNA inhibition
    21047800
    SM4819
    GGACAUUCAGAACAAGAAAUU
    UUUCUUGUUCUGAAUGUCCUU
    unlocked nucleic acid
    unlocked nucleic acid
    20,21
    5,20,21
    Sugar
    Sugar
    37 percent target mRNA inhibition
    21047800
    SM4820
    GGACAUUCAGAACAAGAAAUU
    UUUCUUGUUCUGAAUGUCCUU
    unlocked nucleic acid
    unlocked nucleic acid
    20,21
    6,20,21
    Sugar
    Sugar
    57 percent target mRNA inhibition
    21047800
    SM4821
    GGACAUUCAGAACAAGAAAUU
    UUUCUUGUUCUGAAUGUCCUU
    unlocked nucleic acid
    unlocked nucleic acid
    20,21
    7,20,21
    Sugar
    Sugar
    78 percent target mRNA inhibition
    21047800
    SM4822
    GGACAUUCAGAACAAGAAAUU
    UUUCUUGUUCUGAAUGUCCUU
    unlocked nucleic acid
    unlocked nucleic acid
    20,21
    10,20,21
    Sugar
    Sugar
    17 percent target mRNA inhibition
    21047800
    SM4823
    ACAGAGUCCCUCAAACAGAUU
    UCUGUUUGAGGGACUCUGUUU
    Thymidine
    Thymidine
    20,21
    20,21
    Sugar
    Sugar
    95 percent target mRNA inhibition
    21047800
    SM4824
    UACAGAGUCCCUCAAACAGAUU
    UCUGUUUGAGGGACUCUGUUU
    unlocked nucleic acid
    unlocked nucleic acid
    1,20,21
    20,21
    Sugar
    Sugar
    95 percent target mRNA inhibition
    21047800
    SM4825
    ACAGAGUCCCUCAAACAGAUU
    UCUGUUUGAGGGACUCUGUUU
    unlocked nucleic acid
    unlocked nucleic acid
    1,20,21
    20,21
    Sugar
    Sugar
    94 percent target mRNA inhibition
    21047800
    SM4826
    ACAGAGUCCCUCAAACAGAUU
    UCUGUUUGAGGGACUCUGUUU
    unlocked nucleic acid
    unlocked nucleic acid
    1,20,21
    20,21
    Sugar
    Sugar
    92 percent target mRNA inhibition
    21047800
    SM4827
    ACAGAGUCCCUCAAACAGAUU
    UCUGUUUGAGGGACUCUGUUU
    unlocked nucleic acid
    unlocked nucleic acid
    1,20,21
    20,21
    Sugar
    Sugar
    91 percent target mRNA inhibition
    21047800