SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM4814 |
GGACAUUCAGAACAAGAAATT UUUCUUGUUCUGAAUGUCCTT |
Thymidine Thymidine |
20,21 20,21 |
Sugar Sugar |
80 percent target mRNA inhibition | 21047800 |
SM4815 |
GGACAUUCAGAACAAGAAAUU UUUCUUGUUCUGAAUGUCCUU |
unlocked nucleic acid unlocked nucleic acid |
20,21 1,20,21 |
Sugar Sugar |
75 percent target mRNA inhibition | 21047800 |
SM4816 |
GGACAUUCAGAACAAGAAAUU UUUCUUGUUCUGAAUGUCCUU |
unlocked nucleic acid unlocked nucleic acid |
20,21 2,20,21 |
Sugar Sugar |
36 percent target mRNA inhibition | 21047800 |
SM4817 |
GGACAUUCAGAACAAGAAAUU UUUCUUGUUCUGAAUGUCCUU |
unlocked nucleic acid unlocked nucleic acid |
20,21 3,20,21 |
Sugar Sugar |
0 percent target mRNA inhibition | 21047800 |
SM4818 |
GGACAUUCAGAACAAGAAAUU UUUCUUGUUCUGAAUGUCCUU |
unlocked nucleic acid unlocked nucleic acid |
20,21 4,20,21 |
Sugar Sugar |
50 percent target mRNA inhibition | 21047800 |
SM4819 |
GGACAUUCAGAACAAGAAAUU UUUCUUGUUCUGAAUGUCCUU |
unlocked nucleic acid unlocked nucleic acid |
20,21 5,20,21 |
Sugar Sugar |
37 percent target mRNA inhibition | 21047800 |
SM4820 |
GGACAUUCAGAACAAGAAAUU UUUCUUGUUCUGAAUGUCCUU |
unlocked nucleic acid unlocked nucleic acid |
20,21 6,20,21 |
Sugar Sugar |
57 percent target mRNA inhibition | 21047800 |
SM4821 |
GGACAUUCAGAACAAGAAAUU UUUCUUGUUCUGAAUGUCCUU |
unlocked nucleic acid unlocked nucleic acid |
20,21 7,20,21 |
Sugar Sugar |
78 percent target mRNA inhibition | 21047800 |
SM4822 |
GGACAUUCAGAACAAGAAAUU UUUCUUGUUCUGAAUGUCCUU |
unlocked nucleic acid unlocked nucleic acid |
20,21 10,20,21 |
Sugar Sugar |
17 percent target mRNA inhibition | 21047800 |
SM4823 |
ACAGAGUCCCUCAAACAGAUU UCUGUUUGAGGGACUCUGUUU |
Thymidine Thymidine |
20,21 20,21 |
Sugar Sugar |
95 percent target mRNA inhibition | 21047800 |
SM4824 |
UACAGAGUCCCUCAAACAGAUU UCUGUUUGAGGGACUCUGUUU |
unlocked nucleic acid unlocked nucleic acid |
1,20,21 20,21 |
Sugar Sugar |
95 percent target mRNA inhibition | 21047800 |
SM4825 |
ACAGAGUCCCUCAAACAGAUU UCUGUUUGAGGGACUCUGUUU |
unlocked nucleic acid unlocked nucleic acid |
1,20,21 20,21 |
Sugar Sugar |
94 percent target mRNA inhibition | 21047800 |
SM4826 |
ACAGAGUCCCUCAAACAGAUU UCUGUUUGAGGGACUCUGUUU |
unlocked nucleic acid unlocked nucleic acid |
1,20,21 20,21 |
Sugar Sugar |
92 percent target mRNA inhibition | 21047800 |
SM4827 |
ACAGAGUCCCUCAAACAGAUU UCUGUUUGAGGGACUCUGUUU |
unlocked nucleic acid unlocked nucleic acid |
1,20,21 20,21 |
Sugar Sugar |
91 percent target mRNA inhibition | 21047800 |