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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 22236254 are 10
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4534
    GGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    2-Deoxyribonucleotide
    0
    24,25
    0
    Sugar
    0
    70 percent target mRNA inhibition
    22236254
    SM4535
    GGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    2-Deoxyribonucleotide* 1-Aminohexane
    0
    24,25 * 25
    0
    Sugar; Phosphate
    0
    79 percent target mRNA inhibition
    22236254
    SM4536
    GGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    2-Deoxyribonucleotide
    1-Aminohexane
    24,25
    27
    Sugar
    Phosphate
    53 percent target mRNA inhibition
    22236254
    SM4537
    GGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    2-Deoxyribonucleotide* 1-Aminohexane
    1-Aminohexane
    24,25 * 25
    27
    Sugar; Phosphate
    Phosphate
    45 percent target mRNA inhibition
    22236254
    SM4538
    GGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    2-Deoxyribonucleotide
    1-Aminohexane
    24,25
    1
    Sugar
    Phosphate
    78 percent target mRNA inhibition
    22236254
    SM4539
    GGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    2-Deoxyribonucleotide* 1-Aminohexane
    1-Aminohexane
    24,25 * 25
    1
    Sugar; Phosphate
    Phosphate
    45 percent target mRNA inhibition
    22236254
    SM4540
    GGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    1-Aminohexane* 2-Deoxyribonucleotide
    0
    1 * 24,25
    0
    Phosphate; Sugar
    0
    69 percent target mRNA inhibition
    22236254
    SM4541
    GGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    1-Aminohexane* 2-Deoxyribonucleotide
    1-Aminohexane
    1 * 24,25
    27
    Phosphate; Sugar
    Phosphate
    45 percent target mRNA inhibition
    22236254
    SM4542
    GGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    1-Aminohexane* 2-Deoxyribonucleotide
    1-Aminohexane
    1 * 24,25
    1
    Phosphate; Sugar
    Phosphate
    56 percent target mRNA inhibition
    22236254
    SM4543
    GGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    1-Aminohexane* 2-Deoxyribonucleotide* N-hexylhexadecanamide
    1-Aminohexane
    1 * 24,25 * 25
    1
    Phosphate; Sugar
    Phosphate
    82 percent target mRNA inhibition
    22236254