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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 22253019 are 360
    Results from 250 - 275
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM5208
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    92.16 percent target mRNA inhibition
    22253019
    SM5209
    CUUUAACAAUUCCUGAAAUUU
    ATTTCAGGAATTGTTAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    5.13 percent target mRNA inhibition
    22253019
    SM5210
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    95.9 percent target mRNA inhibition
    22253019
    SM5211
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14
    Base; Sugar; Sugar
    Sugar
    93.06 percent target mRNA inhibition
    22253019
    SM5212
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,6,7,8,9,10,13,16,17,18,19 * 2,3,4,5,11,12,14,15 * 20,21
    Base; Sugar; Sugar
    Sugar
    91.48 percent target mRNA inhibition
    22253019
    SM5213
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,6,7,8,9,10,13,16,17,18,19 * 2,3,4,5,11,12,14,15 * 20,21
    Base; Sugar; Sugar
    Sugar
    22.31 percent target mRNA inhibition
    22253019
    SM5214
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Fluoro
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,6,7,8,9,10,13,16,17,18,19,20,21 * 2,3,4,5,11,12,14,15
    Base; Sugar; Sugar
    Sugar
    94.13 percent target mRNA inhibition
    22253019
    SM5215
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,6,7,8,9,10,13,16,17,18,19 * 2,3,4,5,11,12,14,15 * 20,21
    Base; Sugar; Sugar
    Sugar
    93.1 percent target mRNA inhibition
    22253019
    SM5216
    CUUUAACAAUUCCUGAAAUUU
    ATTTCAGGAATTGTTAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,6,7,8,9,10,13,16,17,18,19 * 2,3,4,5,11,12,14,15 * 20,21
    Base; Sugar; Sugar
    Sugar
    93.27 percent target mRNA inhibition
    22253019
    SM5217
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,6,7,8,9,10,13,16,17,18,19 * 2,3,4,5,11,12,15,20,21 * 14
    Base; Sugar; Sugar
    Sugar
    95.36 percent target mRNA inhibition
    22253019
    SM5218
    CUUUAACAAUUCCUGAAAUUU
    UCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    0 percent target mRNA inhibition
    22253019
    SM5219
    CUUUAACAAUUCCUGAAAUUU
    TCAGGAATTGTTAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    32.68 percent target mRNA inhibition
    22253019
    SM5220
    CUUUAACAAUUCCUGAAAUUU
    UCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    89.33 percent target mRNA inhibition
    22253019
    SM5221
    CUUUAACAAUUCCUGAAAUUU
    UCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,12,13,14,15,16,17,18 * 11
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    0 percent target mRNA inhibition
    22253019
    SM5222
    CUUUAACAAUUCCUGAAAUUU
    UCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,8,9,11,12 * 3,4,5,6,7,10,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    21.59 percent target mRNA inhibition
    22253019
    SM5223
    CUUUAACAAUUCCUGAAAUUU
    UCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,8,9,11,12 * 3,4,5,6,7,10,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    1.51 percent target mRNA inhibition
    22253019
    SM5224
    CUUUAACAAUUCCUGAAAUUU
    UCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,8,9,11,12 * 3,4,5,6,7,10,13,14,15,16,17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    0 percent target mRNA inhibition
    22253019
    SM5225
    CUUUAACAAUUCCUGAAAUUU
    UCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,8,9,11,12 * 3,4,5,6,7,10,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    71.62 percent target mRNA inhibition
    22253019
    SM5226
    CUUUAACAAUUCCUGAAAUUU
    TCAGGAATTGTTAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,8,9,11,12 * 3,4,5,6,7,10,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    70.88 percent target mRNA inhibition
    22253019
    SM5227
    CUUUAACAAUUCCUGAAAUUU
    UCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,8,9,12,17,18 * 3,4,5,6,7,10,13,14,15,16 * 11
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    49.21 percent target mRNA inhibition
    22253019
    SM5228
    UCAUCACACUGAAUACCAAUU
    UUGGUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    94.24 percent target mRNA inhibition
    22253019
    SM5229
    UCAUCACACUGAAUACCAAUU
    TTGGTATTCAGTGTGATGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    43.28 percent target mRNA inhibition
    22253019
    SM5230
    UCAUCACACUGAAUACCAAUU
    UUGGUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    93.32 percent target mRNA inhibition
    22253019
    SM5231
    UCAUCACACUGAAUACCAAUU
    UUGGUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    94.42 percent target mRNA inhibition
    22253019
    SM5232
    UCAUCACACUGAAUACCAAUU
    UUGGUAUUCAGUGUGAUGAUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,5,7,8,9,12,14,17 * 3,4,6,10,11,13,15,16,18,19 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    93 percent target mRNA inhibition
    22253019