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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 22253019 are 360
    Results from 325 - 350
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM5283
    ACAACAGACUUUAAUGUAAUU
    CAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,9,10,11,13,14,16 * 2,5,6,7,8,12,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    50.27 percent target mRNA inhibition
    22253019
    SM5284
    ACAACAGACUUUAAUGUAAUU
    CAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,9,10,11,13,14,16 * 2,5,6,7,8,12,15,17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    79.41 percent target mRNA inhibition
    22253019
    SM5285
    ACAACAGACUUUAAUGUAAUU
    CAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,9,10,11,13,14,16 * 2,5,6,7,8,12,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    73.27 percent target mRNA inhibition
    22253019
    SM5286
    ACAACAGACUUUAAUGUAAUU
    CATTAAAGTCTGTTGTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,9,10,11,13,14,16 * 2,5,6,7,8,12,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    67.94 percent target mRNA inhibition
    22253019
    SM5287
    ACAACAGACUUUAAUGUAAUU
    CAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,9,10,13,14,16,17,18 * 2,5,6,7,8,12,15 * 11
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    48.19 percent target mRNA inhibition
    22253019
    SM5288
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    93.09 percent target mRNA inhibition
    22253019
    SM5289
    AAAUCAUGGUGAAAUAAAAUU
    TTTTATTTCACCATGATTTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    46.52 percent target mRNA inhibition
    22253019
    SM5290
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    92.8 percent target mRNA inhibition
    22253019
    SM5291
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    72.84 percent target mRNA inhibition
    22253019
    SM5292
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    94.18 percent target mRNA inhibition
    22253019
    SM5293
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    92.8 percent target mRNA inhibition
    22253019
    SM5294
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16,20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    92.98 percent target mRNA inhibition
    22253019
    SM5295
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    91.47 percent target mRNA inhibition
    22253019
    SM5296
    AAAUCAUGGUGAAAUAAAAUU
    TTTTATTTCACCATGATTTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,6,7,8,9,11,12,14,17,18,19* 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    73.8 percent target mRNA inhibition
    22253019
    SM5297
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,6,7,8,9,11,12,17,18,19,20,21 * 5,10,13,15,16 * 14
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    89.08 percent target mRNA inhibition
    22253019
    SM5298
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    93.16 percent target mRNA inhibition
    22253019
    SM5299
    AAAUCAUGGUGAAAUAAAAUU
    TTTTATTTCACCATGATTTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    42.39 percent target mRNA inhibition
    22253019
    SM5300
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    93.42 percent target mRNA inhibition
    22253019
    SM5301
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14
    Base; Sugar; Sugar
    Sugar
    69.9 percent target mRNA inhibition
    22253019
    SM5302
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Sugar
    93.43 percent target mRNA inhibition
    22253019
    SM5303
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Sugar
    92.24 percent target mRNA inhibition
    22253019
    SM5304
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,6,7,8,9,11,12,14,17,18,19* 5,10,13,15,16,20,21
    Base; Sugar; Sugar
    Sugar
    93.28 percent target mRNA inhibition
    22253019
    SM5305
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Sugar
    93.72 percent target mRNA inhibition
    22253019
    SM5306
    AAAUCAUGGUGAAAUAAAAUU
    TTTTATTTCACCATGATTTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Sugar
    74.7 percent target mRNA inhibition
    22253019
    SM5307
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,6,7,8,9,11,12,17,18,19,20,21 * 5,10,13,15,16 * 14
    Base; Sugar; Sugar
    Sugar
    87.07 percent target mRNA inhibition
    22253019