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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 22253019 are 360
    Results from 50 - 75
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM5008
    CACAAUGCAUUUAGAUCAAUU
    AUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    32.12 percent target mRNA inhibition
    22253019
    SM5009
    CACAAUGCAUUUAGAUCAAUU
    ATCTAAATGCATTGTGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    10.62 percent target mRNA inhibition
    22253019
    SM5010
    CACAAUGCAUUUAGAUCAAUU
    AUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    91.54 percent target mRNA inhibition
    22253019
    SM5011
    CACAAUGCAUUUAGAUCAAUU
    AUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,12,13,14,15,16,17,18 * 11
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    15.3 percent target mRNA inhibition
    22253019
    SM5012
    CACAAUGCAUUUAGAUCAAUU
    AUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,5,6,7,9,11,14,16 * 2,3,4,8,10,12,13,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    81.01 percent target mRNA inhibition
    22253019
    SM5013
    CACAAUGCAUUUAGAUCAAUU
    AUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,5,6,7,9,11,14,16 * 2,3,4,8,10,12,13,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    66.94 percent target mRNA inhibition
    22253019
    SM5014
    CACAAUGCAUUUAGAUCAAUU
    AUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Methoxy* 2-Fluoro
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,5,6,7,9,11,14,16,17,18 * 2,3,4,8,10,12,13,15
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    29.77 percent target mRNA inhibition
    22253019
    SM5015
    CACAAUGCAUUUAGAUCAAUU
    AUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,5,6,7,9,11,14,16 * 2,3,4,8,10,12,13,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    67.37 percent target mRNA inhibition
    22253019
    SM5016
    CACAAUGCAUUUAGAUCAAUU
    ATCTAAATGCATTGTGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,5,6,7,9,11,14,16 * 2,3,4,8,10,12,13,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    33.35 percent target mRNA inhibition
    22253019
    SM5017
    CACAAUGCAUUUAGAUCAAUU
    AUCUAAAUGCAUUGUGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,5,6,7,9,14,16 * 2,3,4,8,10,12,13,15,17,18 * 11
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    51.92 percent target mRNA inhibition
    22253019
    SM5018
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    97.86 percent target mRNA inhibition
    22253019
    SM5019
    CUUUAACAAUUCCUGAAAUUU
    ATTTCAGGAATTGTTAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    57.97 percent target mRNA inhibition
    22253019
    SM5020
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    97.54 percent target mRNA inhibition
    22253019
    SM5021
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    97.78 percent target mRNA inhibition
    22253019
    SM5022
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,6,7,8,9,10,13,16,17,18,19 * 2,3,4,5,11,12,14,15 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    96.62 percent target mRNA inhibition
    22253019
    SM5023
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,6,7,8,9,10,13,16,17,18,19 * 2,3,4,5,11,12,14,15 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    54.35 percent target mRNA inhibition
    22253019
    SM5024
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Methoxy* 2-Fluoro
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,6,7,8,9,10,13,16,17,18,19,20,21* 2,3,4,5,11,12,14,15
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    96.81 percent target mRNA inhibition
    22253019
    SM5025
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,6,7,8,9,10,13,16,17,18,19 * 2,3,4,5,11,12,14,15 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    98.23 percent target mRNA inhibition
    22253019
    SM5026
    CUUUAACAAUUCCUGAAAUUU
    ATTTCAGGAATTGTTAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,6,7,8,9,10,13,16,17,18,19 * 2,3,4,5,11,12,14,15 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    69.03 percent target mRNA inhibition
    22253019
    SM5027
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,6,7,8,9,10,13,16,17,18,19 * 2,3,4,5,11,12,15,20,21 * 14
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    97.99 percent target mRNA inhibition
    22253019
    SM5028
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    98.32 percent target mRNA inhibition
    22253019
    SM5029
    CUUUAACAAUUCCUGAAAUUU
    ATTTCAGGAATTGTTAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    54.79 percent target mRNA inhibition
    22253019
    SM5030
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    97.3 percent target mRNA inhibition
    22253019
    SM5031
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14
    Base; Sugar; Sugar
    Sugar
    97.63 percent target mRNA inhibition
    22253019
    SM5032
    CUUUAACAAUUCCUGAAAUUU
    AUUUCAGGAAUUGUUAAAGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,6,7,8,9,10,13,16,17,18,19 * 2,3,4,5,11,12,14,15 * 20,21
    Base; Sugar; Sugar
    Sugar
    96.81 percent target mRNA inhibition
    22253019