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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 22253019 are 360
    Results from 125 - 150
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM5083
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,4,6,7,12,13,14,16,17,19 * 3,5,8,9,10,11,15,18 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    74.93 percent target mRNA inhibition
    22253019
    SM5084
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,4,6,7,12,13,14,16,17,19 * 3,5,8,9,10,11,15,18,20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    92.8 percent target mRNA inhibition
    22253019
    SM5085
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,4,6,7,12,13,14,16,17,19 * 3,5,8,9,10,11,15,18 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    91.2 percent target mRNA inhibition
    22253019
    SM5086
    ACAACAGACUUUAAUGUAAUU
    TTACATTAAAGTCTGTTGTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,4,6,7,12,13,14,16,17,19 * 3,5,8,9,10,11,15,18 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    63.24 percent target mRNA inhibition
    22253019
    SM5087
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,4,6,7,12,13,16,17,19,20,21 * 3,5,8,9,10,11,15,18 * 14
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    87.66 percent target mRNA inhibition
    22253019
    SM5088
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    92.95 percent target mRNA inhibition
    22253019
    SM5089
    ACAACAGACUUUAAUGUAAUU
    TTACATTAAAGTCTGTTGTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    36.37 percent target mRNA inhibition
    22253019
    SM5090
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    91.35 percent target mRNA inhibition
    22253019
    SM5091
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14
    Base; Sugar; Sugar
    Sugar
    89.53 percent target mRNA inhibition
    22253019
    SM5092
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,4,6,7,12,13,14,16,17,19 * 3,5,8,9,10,11,15,18 * 20,21
    Base; Sugar; Sugar
    Sugar
    92.62 percent target mRNA inhibition
    22253019
    SM5093
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,4,6,7,12,13,14,16,17,19 * 3,5,8,9,10,11,15,18 * 20,21
    Base; Sugar; Sugar
    Sugar
    76.42 percent target mRNA inhibition
    22253019
    SM5094
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,4,6,7,12,13,14,16,17,19 * 3,5,8,9,10,11,15,18,20,21
    Base; Sugar; Sugar
    Sugar
    94.37 percent target mRNA inhibition
    22253019
    SM5095
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,4,6,7,12,13,14,16,17,19 * 3,5,8,9,10,11,15,18 * 20,21
    Base; Sugar; Sugar
    Sugar
    92.73 percent target mRNA inhibition
    22253019
    SM5096
    ACAACAGACUUUAAUGUAAUU
    TTACATTAAAGTCTGTTGTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,4,6,7,12,13,14,16,17,19 * 3,5,8,9,10,11,15,18 * 20,21
    Base; Sugar; Sugar
    Sugar
    67.24 percent target mRNA inhibition
    22253019
    SM5097
    ACAACAGACUUUAAUGUAAUU
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,4,6,7,12,13,16,17,19,20,21 * 3,5,8,9,10,11,15,18 * 14
    Base; Sugar; Sugar
    Sugar
    89.08 percent target mRNA inhibition
    22253019
    SM5098
    ACAACAGACUUUAAUGUAAUU
    CAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    54 percent target mRNA inhibition
    22253019
    SM5099
    ACAACAGACUUUAAUGUAAUU
    CATTAAAGTCTGTTGTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    18.64 percent target mRNA inhibition
    22253019
    SM5100
    ACAACAGACUUUAAUGUAAUU
    CAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    77.39 percent target mRNA inhibition
    22253019
    SM5101
    ACAACAGACUUUAAUGUAAUU
    CAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,12,13,14,15,16,17,18 * 11
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    69.98 percent target mRNA inhibition
    22253019
    SM5102
    ACAACAGACUUUAAUGUAAUU
    CAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,9,10,11,13,14,16 * 2,5,6,7,8,12,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    65.06 percent target mRNA inhibition
    22253019
    SM5103
    ACAACAGACUUUAAUGUAAUU
    CAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,9,10,11,13,14,16 * 2,5,6,7,8,12,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    32.43 percent target mRNA inhibition
    22253019
    SM5104
    ACAACAGACUUUAAUGUAAUU
    CAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,9,10,11,13,14,16 * 2,5,6,7,8,12,15,17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    81.1 percent target mRNA inhibition
    22253019
    SM5105
    ACAACAGACUUUAAUGUAAUU
    CAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,9,10,11,13,14,16 * 2,5,6,7,8,12,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    70.54 percent target mRNA inhibition
    22253019
    SM5106
    ACAACAGACUUUAAUGUAAUU
    CATTAAAGTCTGTTGTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,9,10,11,13,14,16 * 2,5,6,7,8,12,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    31.5 percent target mRNA inhibition
    22253019
    SM5107
    ACAACAGACUUUAAUGUAAUU
    CAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,9,10,13,14,16,17,18 * 2,5,6,7,8,12,15 * 11
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    59.81 percent target mRNA inhibition
    22253019