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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 22253019 are 360
    Results from 150 - 175
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM5108
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    95.08 percent target mRNA inhibition
    22253019
    SM5109
    AAAUCAUGGUGAAAUAAAAUU
    TTTTATTTCACCATGATTTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    30.09 percent target mRNA inhibition
    22253019
    SM5110
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    95.82 percent target mRNA inhibition
    22253019
    SM5111
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    79.02 percent target mRNA inhibition
    22253019
    SM5112
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    96.2 percent target mRNA inhibition
    22253019
    SM5113
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    95.34 percent target mRNA inhibition
    22253019
    SM5114
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16,20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    95.54 percent target mRNA inhibition
    22253019
    SM5115
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    95.54 percent target mRNA inhibition
    22253019
    SM5116
    AAAUCAUGGUGAAAUAAAAUU
    TTTTATTTCACCATGATTTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,6,7,8,9,11,12,14,17,18,19* 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    78.67 percent target mRNA inhibition
    22253019
    SM5117
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,3,4,6,7,8,9,11,12,17,18,19,20,21 * 5,10,13,15,16 * 14
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    91.11 percent target mRNA inhibition
    22253019
    SM5118
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    95.16 percent target mRNA inhibition
    22253019
    SM5119
    AAAUCAUGGUGAAAUAAAAUU
    TTTTATTTCACCATGATTTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    31.27 percent target mRNA inhibition
    22253019
    SM5120
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    95.96 percent target mRNA inhibition
    22253019
    SM5121
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14
    Base; Sugar; Sugar
    Sugar
    79.33 percent target mRNA inhibition
    22253019
    SM5122
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Sugar
    96.51 percent target mRNA inhibition
    22253019
    SM5123
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Sugar
    95.96 percent target mRNA inhibition
    22253019
    SM5124
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,6,7,8,9,11,12,14,17,18,19* 5,10,13,15,16,20,21
    Base; Sugar; Sugar
    Sugar
    95.72 percent target mRNA inhibition
    22253019
    SM5125
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Sugar
    96.07 percent target mRNA inhibition
    22253019
    SM5126
    AAAUCAUGGUGAAAUAAAAUU
    TTTTATTTCACCATGATTTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,6,7,8,9,11,12,14,17,18,19 * 5,10,13,15,16 * 20,21
    Base; Sugar; Sugar
    Sugar
    76.93 percent target mRNA inhibition
    22253019
    SM5127
    AAAUCAUGGUGAAAUAAAAUU
    UUUUAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,6,7,8,9,11,12,17,18,19,20,21 * 5,10,13,15,16 * 14
    Base; Sugar; Sugar
    Sugar
    91.78 percent target mRNA inhibition
    22253019
    SM5128
    AAAUCAUGGUGAAAUAAAAUU
    UAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    47.26 percent target mRNA inhibition
    22253019
    SM5129
    AAAUCAUGGUGAAAUAAAAUU
    TATTTCACCATGATTTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    12.07 percent target mRNA inhibition
    22253019
    SM5130
    AAAUCAUGGUGAAAUAAAAUU
    UAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    61.82 percent target mRNA inhibition
    22253019
    SM5131
    AAAUCAUGGUGAAAUAAAAUU
    UAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,12,13,14,15,16,17,18 * 11
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    60.06 percent target mRNA inhibition
    22253019
    SM5132
    AAAUCAUGGUGAAAUAAAAUU
    UAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,5,6,8,9,11,14,15,16 * 2,7,10,12,13 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    1.88 percent target mRNA inhibition
    22253019