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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 22253019 are 360
    Results from 175 - 200
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM5133
    AAAUCAUGGUGAAAUAAAAUU
    UAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,5,6,8,9,11,14,15,16 * 2,7,10,12,13 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    52.1 percent target mRNA inhibition
    22253019
    SM5134
    AAAUCAUGGUGAAAUAAAAUU
    UAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,5,6,8,9,11,14,15,16 * 2,7,10,12,13,17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    66.52 percent target mRNA inhibition
    22253019
    SM5135
    AAAUCAUGGUGAAAUAAAAUU
    UAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,5,6,8,9,11,14,15,16 * 2,7,10,12,13 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    41.97 percent target mRNA inhibition
    22253019
    SM5136
    AAAUCAUGGUGAAAUAAAAUU
    TATTTCACCATGATTTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,5,6,8,9,11,14,15,16 * 2,7,10,12,13 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    28.25 percent target mRNA inhibition
    22253019
    SM5137
    AAAUCAUGGUGAAAUAAAAUU
    UAUUUCACCAUGAUUUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,5,6,8,9,14,15,16,17,18 * 2,7,10,12,13 * 11
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    58.65 percent target mRNA inhibition
    22253019
    SM5138
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    98.52 percent target mRNA inhibition
    22253019
    SM5139
    CCAGUAAGGCUUCUCUUAAUU
    TTAAGAGAAGCCTTACTGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    21.62 percent target mRNA inhibition
    22253019
    SM5140
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    97.96 percent target mRNA inhibition
    22253019
    SM5141
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Deoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14
    Base; Sugar; Sugar
    Sugar
    85.84 percent target mRNA inhibition
    22253019
    SM5142
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,14,16,17 * 3,4,5,6,7,8,9,10,15,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    98.81 percent target mRNA inhibition
    22253019
    SM5143
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,14,16,17 * 3,4,5,6,7,8,9,10,15,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    84.59 percent target mRNA inhibition
    22253019
    SM5144
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Methoxy* 2-Fluoro
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 3,4,5,6,7,8,9,10,15,18,19,20,21 * 1,2,11,12,13,14,16,17
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    97.87 percent target mRNA inhibition
    22253019
    SM5145
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Methoxy* 2-Fluoro
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 20,21 * 3,4,5,6,7,8,9,10,15,18,19
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    98.4 percent target mRNA inhibition
    22253019
    SM5146
    CCAGUAAGGCUUCUCUUAAUU
    TTAAGAGAAGCCTTACTGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Hydroxy* 2-Methoxy* 2-Fluoro
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,11,12,13,14,16,17 * 20,21 * 3,4,5,6,7,8,9,10,15,18,19
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    96.21 percent target mRNA inhibition
    22253019
    SM5147
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,11,12,13,16,17,20,21 * 3,4,5,6,7,8,9,10,15,18,19 * 14
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    96.74 percent target mRNA inhibition
    22253019
    SM5148
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 *20,21
    Base; Sugar; Sugar
    Sugar
    98.15 percent target mRNA inhibition
    22253019
    SM5149
    CCAGUAAGGCUUCUCUUAAUU
    TTAAGAGAAGCCTTACTGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    0 percent target mRNA inhibition
    22253019
    SM5150
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    98.7 percent target mRNA inhibition
    22253019
    SM5151
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14
    Base; Sugar; Sugar
    Sugar
    88.17 percent target mRNA inhibition
    22253019
    SM5152
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,14,16,17 * 3,4,5,6,7,8,9,10,15,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    98.1 percent target mRNA inhibition
    22253019
    SM5153
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,14,16,17 * 3,4,5,6,7,8,9,10,15,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    84.66 percent target mRNA inhibition
    22253019
    SM5154
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,14,16,17 * 3,4,5,6,7,8,9,10,15,18,19,20,21
    Base; Sugar; Sugar
    Sugar
    97.68 percent target mRNA inhibition
    22253019
    SM5155
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,14,16,17 * 3,4,5,6,7,8,9,10,15,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    98.31 percent target mRNA inhibition
    22253019
    SM5156
    CCAGUAAGGCUUCUCUUAAUU
    TTAAGAGAAGCCTTACTGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,14,16,17 * 3,4,5,6,7,8,9,10,15,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    96.51 percent target mRNA inhibition
    22253019
    SM5157
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,16,17,20,21 * 3,4,5,6,7,8,9,10,15,18,19 * 14
    Base; Sugar; Sugar
    Sugar
    95.94 percent target mRNA inhibition
    22253019