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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 22411910 are 9
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2163
    GCGCUGCUGGUGCCAACCCTT
    GGGUUGGCACCAGCAGCGCTT
    2-Deoxy
    2-Deoxy
    20,21
    20,21
    Sugar
    Sugar
    74 percent target mRNA inhibition
    22411910
    SM2164
    GCGCUGCUGGUGCCAACCCTT
    GGGUUGGCACCAGCAGCGCTT
    2-O-Methyl-4-Thioribose* 2-Deoxy
    2-O-Methyl-4-Thioribose* 2-Deoxy
    1,2,3,4,16,17,18,19 * 20,21
    16,17,18,19 * 20,21
    Sugar
    Sugar
    48 percent target mRNA inhibition
    22411910
    SM2165
    GCGCUGCUGGUGCCAACCCTT
    GGGUUGGCACCAGCAGCGCTT
    2-O-Methyl-4-Thioribose* 2-Deoxy
    2-O-Methyl-4-Thioribose* 2-Deoxy
    1,2,3,4,16,17,18,19 * 20,21
    1,2,18,19 * 20,21
    Sugar
    Sugar
    48 percent target mRNA inhibition
    22411910
    SM2166
    GCGCUGCUGGUGCCAACCCTT
    GGGUUGGCACCAGCAGCGCTT
    2-O-Methyl-4-Thioribose* 2-Deoxy
    2-Deoxy
    1,2,3,4,16,17,18,19 * 20,21
    20,21
    Sugar
    Sugar
    60 percent target mRNA inhibition
    22411910
    SM2167
    GCGCUGCUGGUGCCAACCCTT
    GGGUUGGCACCAGCAGCGCTT
    2-O-Methyl-4-Thioribose* 2-Deoxy
    2-Deoxy
    1,2,3,4,18,19 * 20,21
    20,21
    Sugar
    Sugar
    66 percent target mRNA inhibition
    22411910
    SM2168
    GCGCUGCUGGUGCCAACCCTT
    GGGUUGGCACCAGCAGCGCTT
    2-O-Methyl-4-Thioribose* 2-Deoxy
    2-Deoxy
    1,2,3,4 * 20,21
    20,21
    Sugar
    Sugar
    64 percent target mRNA inhibition
    22411910
    SM2169
    GCGCUGCUGGUGCCAACCCTT
    GGGUUGGCACCAGCAGCGCTT
    2-O-Methyl-4-Thioribose* 2-Deoxy
    2-Deoxy
    1,2,3,17,18,19 * 20,21
    20,21
    Sugar
    Sugar
    80 percent target mRNA inhibition
    22411910
    SM2170
    GCGCUGCUGGUGCCAACCCTT
    GGGUUGGCACCAGCAGCGCTT
    2-O-Methyl-4-Thioribose* 2-Deoxy
    2-Deoxy
    1,2,3,17,18,19 * 20,21
    20,21
    Sugar
    Sugar
    IC-50 = 26.3 nM for target mRNA
    22411910
    SM2171
    GCGCUGCUGGUGCCAACCCTT
    GGGUUGGCACCAGCAGCGCTT
    4-Thioribose* 2-Deoxy
    2-Deoxy
    1,2,3,17,18,19 * 20,21
    20,21
    Sugar
    Sugar
    IC-50 = 29.2 nM for target mRNA
    22411910