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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for US20120088815A1, EP2415869A1 are 596
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM3441	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	2-Deoxy-2-Fluoro 0	2,4,6,7,11,12,13,15,17 0	Sugar 0	27 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3442	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	0 2-O-Methyl	0 1,3,4,6,8,12,13,14,17,19,21,22,23	0 Sugar	0 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3443	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	2-O-Methyl 2-O-Methyl	7,8 14,15	Sugar Sugar	27 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3444	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	7 14,15	Sugar Sugar	44 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3445	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	2-O-Methyl 2-O-Methyl	7,8 15	Sugar Sugar	56 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3446	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	2-O-Methyl 2-O-Methyl	7 15	Sugar Sugar	81 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3447	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	2-O-Methyl 2-O-Methyl	7 14	Sugar Sugar	49 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3448	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	0 2-Deoxy-2-Fluoro	0 14,15	0 Sugar	49 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3449	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	2-Deoxy-2-Fluoro 0	7 0	Sugar 0	85 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3450	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	0 2-O-Methyl	0 15	0 Sugar	84 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3451	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	2-O-Methyl 2-O-Methyl	7,8 14	Sugar Sugar	23 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3452	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	2-O-Methyl 2-O-Methyl	8 14,15	Sugar Sugar	41 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3453	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	8 14	Sugar Sugar	47 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3454	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	2-O-Methyl 2-O-Methyl	8 15	Sugar Sugar	83 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3455	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	2-O-Methyl 0	7,8 0	Sugar 0	59 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3456	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	0 2-Deoxy-2-Fluoro	0 14	0 Sugar	49 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3457	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	2-O-Methyl 0	8 0	Sugar 0	85 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3459	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	2-O-Methyl 0	7 0	Sugar 0	53 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3460	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	2-Deoxy-2-Fluoro 0	7 0	Sugar 0	78 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3461	AGCGCUUAAAGGGCGGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	2-O-Methyl 2-O-Methyl	7 14	Sugar Sugar	50 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3462	AGCGCUUAAAGGGCGGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	8 15	Sugar Sugar	79 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3463	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	Phosphodiester Phosphodiester	7 14	Sugar Sugar	45 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3464	AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU	2-Deoxy-2-Fluoro 2-Deoxy-2-Fluoro	7 15	Sugar Sugar	51 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3466	AACCCACCACAGCUAGAACUU AAGUUCUAGCUGUGGUGGGUU	0 2-O-Methyl	0 3,4,5,7,9,11,12,13,14,15,16,17,18,20,21	0 Sugar	15 percent target mRNA inhibition	US20120088815A1, EP2415869A1
SM3467	AACCCACCACAGCUAGAACUU AAGUUCUAGCUGUGGUGGGUU	2-Deoxy-2-Fluoro 0	1,2,6,9,11,14,15,17,18,20,21 0	Sugar 0	37 percent target mRNA inhibition	US20120088815A1, EP2415869A1



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