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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for WO2014022739A3 are 11
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM4803	GGAUCAUCUCAAGUCUUACTT GUAAGACUUGAGAUGAUCCTT	Phosphorothioate Phosphorothioate	20 20	Sugar Sugar	IC-50 = 0.0095 nM for target mRNA	WO2014022739A3
SM4804	GGAUCAUCUCAAGUCUUACTT GUAAGACUUGAGAUGAUCCTT	2-Fluororibose* Phosphorothioate 2-Fluororibose* Phosphorothioate	4,5,7,8,9,10,14,15,16,17,19 * 20 4,5,7,8,9,10,14,15,16,17,19 * 20	Sugar Sugar	IC-50 = 0.0074 nM for target mRNA	WO2014022739A3
SM4805	GGAUCAUCUCAAGUCUUACTT GUAAGACUUGAGAUGAUCCTT	2-Fluororibose* Xylo-O-methylribose* Phosphorothioate 2-Fluororibose* Xylo-O-methylribose* Phosphorothioate	4,5,7,8,9,10,15,16,17,19 * 14 * 20 4,5,7,8,9,10,15,16,17,19 * 14 * 20	Sugar Sugar	IC-50 = 0.0076 nM for target mRNA	WO2014022739A3
SM4806	GGAUCAUCUCAAGUCUUACTT GUAAGACUUGAGAUGAUCCTT	2-Fluororibose* Xylo-3-fluororibose* Phosphorothioate 2-Fluororibose* Xylo-3-fluororibose* Phosphorothioate	4,5,7,8,9,10,15,16,17,19 * 14 * 20 4,5,7,8,9,10,15,16,17,19 * 14 * 20	Sugar Sugar	IC-50 = 0.1247 nM for target mRNA	WO2014022739A3
SM4807	GGAUCAUCUCAAGUCUUACTT GUAAGACUUGAGAUGAUCCTT	2-Fluororibose* 3-O-methylribose* Phosphorothioate 2-Fluororibose* 3-O-methylribose* Phosphorothioate	4,5,7,8,9,10,15,16,17,19 * 14 * 20 4,5,7,8,9,10,15,16,17,19 * 14 * 20	Sugar Sugar	IC-50 = 0.0083 nM for target mRNA	WO2014022739A3
SM4808	GGAUCAUCUCAAGUCUUACTT GUAAGACUUGAGAUGAUCCTT	2-Fluororibose* Xylo-3-fluororibose* Phosphorothioate 2-Fluororibose* Xylo-3-fluororibose* Phosphorothioate	4,5,7,8,9,10,15,16,17,19 * 14 * 20 4,5,7,8,9,10,15,16,17,19 * 14 * 20	Sugar Sugar	IC-50 = 0.0086 nM for target mRNA	WO2014022739A3
SM4809	GGAUCAUCUCAAGUCUUACTT GUAAGACUUGAGAUGAUCCTT	2-Fluororibose* Xylo-O-methylribose* Phosphorothioate 2-Fluororibose* Xylo-O-methylribose* Phosphorothioate	4,7,8,9,10,15,16,17,19 * 5,14 * 20 4,7,8,9,10,15,16,17,19 * 5,14 * 20	Sugar Sugar	IC-50 = 0.1822 nM for target mRNA	WO2014022739A3
SM4810	GGAUCAUCUCAAGUCUUACTT GUAAGACUUGAGAUGAUCCTT	2-Fluororibose* Xylo-3-fluororibose* Phosphorothioate 2-Fluororibose* Xylo-3-fluororibose* Phosphorothioate	4,7,8,9,10,15,16,17,19 * 5,14 * 20 4,7,8,9,10,15,16,17,19 * 5,14 * 20	Sugar Sugar	NA	WO2014022739A3
SM4811	GGAUCAUCUCAAGUCUUACTT GUAAGACUUGAGAUGAUCCTT	2-Fluororibose* 3-O-methylribose* Phosphorothioate 2-Fluororibose* 3-O-methylribose* Phosphorothioate	4,7,8,9,10,15,16,17,19 * 5,14 * 20 4,7,8,9,10,15,16,17,19 * 5,14 * 20	Sugar Sugar	IC-50 = 0.0246 nM for target mRNA	WO2014022739A3
SM4812	GGAUCAUCUCAAGUCUUACTT GUAAGACUUGAGAUGAUCCTT	2-Fluororibose* Xylo-3-fluororibose* Phosphorothioate 2-Fluororibose* Phosphorothioate	4,7,8,9,10,15,16,17,19 * 5,14 * 20 4,5,7,8,9,10,14,15,16,17,19 * 20	Sugar Sugar	IC-50 = 0.01 nM for target mRNA	WO2014022739A3
SM4813	GGAUCAUCUCAAGUCUUACTT GUAAGACUUGAGAUGAUCCTT	2-Fluororibose* Phosphorothioate 2-Fluororibose* Xylo-3-fluororibose* Phosphorothioate	4,5,7,8,9,10,14,15,16,17,19 * 20 4,7,8,9,10,15,16,17,19 * 5,14 * 20	Sugar Sugar	NA	WO2014022739A3