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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-Deoxyribonucleotide are 19
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2507
    CGAGGGGAGUACAUCAAGACC
    UCUUGAUGUACUCCCCUCGTT
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2508
    CGAGGGGAGUACAUCAAGATT
    UCUUGAUGUACUCCCCUCGTT
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM4427
    GGCCUUUCACUACUCCUACTT
    GUAGGAGUAGUGAAAGGCCTT
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Base
    Base
    36 percent target mRNA inhibition
    21141919
    SM4432
    GGCCUUUCACUACUCCUACTT
    GUAGGAGUAGUGAAAGGCCTT
    Fluorescein* 2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    1 * 21,22
    20,21
    Base
    Base
    NA
    21141919
    SM4434
    CUUCUUCGUCGAGACCAUGTT
    CAUGGUCUCGACGAAGAAGTT
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Base
    Base
    45 percent target mRNA inhibition
    21141919
    SM4435
    CUUCUUCGUCGAGACCAUGTT
    CAUGGUCUCGACGAAGAAGTT
    [1,1-Biphenyl]-3,5-dimethanol* 2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    1 * 20,21
    20,21
    Base
    Base
    45 percent target mRNA inhibition
    21141919
    SM4436
    CUUCUUCGUCGAGACCAUGTT
    CAUGGUCUCGACGAAGAAGTT
    [3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* 2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    1 * 20,21
    20,21
    Base
    Base
    25 percent target mRNA inhibition
    21141919
    SM4439
    UUUCACUACUCCUACGAGCTT
    GCUCGUAGGAGUAGUGAAATT
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Base
    Base
    0 percent target mRNA inhibition
    21141919
    SM4442
    UUUCACUACUCCUACGAGCTT
    GCUCGUAGGAGUAGUGAAATT
    5-O-methylthymidine
    2-Deoxyribonucleotide
    1
    20,21
    Base
    Base
    31 percent target mRNA inhibition
    21141919
    SM4443
    UAAGAUGUUCAUCGAGUCCTT
    GGACUCGAUGAACAUCUUATT
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Base
    Base
    0 percent target mRNA inhibition
    21141919
    SM4446
    GUCUCGUAGACCGUGCAUCATT
    UGAUGCACGGUCUACGAGACTT
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    21,22
    20,21
    Base
    Base
    NA
    21141919
    SM4462
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGATT
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Sugar
    Sugar
    54 percent target mRNA inhibition
    21985606
    SM4463
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGATT
    Palmitic acid* 2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    1 * 20,21
    20,21
    Phosphate; Sugar
    Sugar
    90 percent target mRNA inhibition
    21985606
    SM4468
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Sugar
    Sugar
    25 percent target mRNA inhibition
    21985606
    SM4469
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    Palmitic acid* 2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    1 * 20,21
    20,21
    Phosphate; Sugar
    Sugar
    73 percent target mRNA inhibition
    21985606
    SM4474
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    21985606
    SM4475
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    Palmitic acid* 2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    1 * 20,21
    20,21
    Phosphate; Sugar
    Sugar
    18 percent target mRNA inhibition
    21985606
    SM4480
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    21985606
    SM4481
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    Palmitic acid* 2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    1 * 20,21
    20,21
    Phosphate; Sugar
    Sugar
    6 percent target mRNA inhibition
    21985606