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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
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  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-Fluoro* Phosphorothioate are 6
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2636
    CGAUGUGUCUAUUGAAGAUUC
    AUCUUCAAUAGACACAUCGGC
    2-Fluoro* Phosphorothioate
    2-Fluoro* Phosphorothioate
    4,6,19,20 * 1,2,3,17,18,19,20
    2,3,4,15,17,18 * 16,17,18,19,20
    Sugar; Phosphate
    Sugar; Phosphate
    15 percent target mRNA inhibition
    18367449
    SM2638
    CGAUGUGUCUAUUGAAGAUUC
    AUCUUCAAUAGACACAUCGGC
    2-Fluoro* Phosphorothioate
    2-Fluoro* Phosphorothioate
    4,6,19,20 * 1,2,3,17,18,19,20
    2,3,4,15,17,18 * 16,17,18,19,20
    Sugar; Phosphate
    Sugar; Phosphate
    34 percent target mRNA inhibition
    18367449
    SM2640
    CGAUGUGUCUAUUGAAGAUUC
    AUCUUCAAUAGACACAUCGGC
    2-Fluoro* Phosphorothioate
    2-Fluoro* Phosphorothioate
    4,6,19,20 * 1,2,3,17,18,19,20
    2,3,4,15,17,18 * 16,17,18,19,20
    Sugar; Phosphate
    Sugar; Phosphate
    63 percent target mRNA inhibition
    18367449
    SM2642
    CGAUGUGUCUAUUGAAGAUUC
    AUCUUCAAUAGACACAUCGGC
    2-Fluoro* Phosphorothioate
    2-Fluoro* Phosphorothioate
    4,6,19,20 * 1,2,3,17,18,19,20
    2,3,4,15,17,18 * 16,17,18,19,20
    Sugar; Phosphate
    Sugar; Phosphate
    66 percent target mRNA inhibition
    18367449
    SM2643
    CGAAGUUUGGAUUCAUCAUUC
    AUGAUGAAUCCAAACUUCGGC
    2-Fluoro* Phosphorothioate
    2-Fluoro* Phosphorothioate
    6,19,20 * 1,2,19,20
    2,17,18 * 1,19,20
    Sugar; Phosphate
    Sugar; Phosphate
    8 percent target mRNA inhibition
    18367449
    SM2993
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    0
    2-Fluoro* Phosphorothioate
    0
    1,2,3,11,12,14,16,17,19 * 4,5,6,7,8,9,10,13,15,18
    0
    Sugar; Phosphate
    22 percent target mRNA inhibition
    12923253