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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-Deoxy* Locked nucleic acid are 143
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM0027
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGC
    2-Deoxy* Locked nucleic acid
    2-O-Methyl
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,22 * 20,21
    2
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0028
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGC
    2-Deoxy* Locked nucleic acid
    2-O-Methyl
    1,2,4,5,7,8,10,11,13,14,16,17,19,22 * 3,6,9,12,15,18,20,21
    2
    Sugar
    Sugar
    1.7 percent target mRNA inhibition
    19282453
    SM0029
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGC
    2-Deoxy* Locked nucleic acid
    2-O-Methyl
    1,3,5,7,8,9,11,13,15,17,19,22 * 2,4,6,10,12,14,16,18,20,21
    2
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0073
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,22 * 20,21
    1 * 21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0074
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    1,2,4,5,7,8,10,11,13,14,16,17,19,22 * 3,6,9,12,15,18,20,21
    1 * 21
    Sugar
    Sugar
    1 percent target mRNA inhibition
    19282453
    SM0075
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    1,3,5,7,8,9,11,13,15,17,19,22 * 2,4,6,10,12,14,16,18,20,21
    1 * 21
    Sugar
    Sugar
    1 percent target mRNA inhibition
    19282453
    SM0118
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,22 * 20,21
    1 * 18
    Sugar
    Sugar
    0.9 percent target mRNA inhibition
    19282453
    SM0119
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    1,2,4,5,7,8,10,11,13,14,16,17,19,22 * 3,6,9,12,15,18,20,21
    1 * 18
    Sugar
    Sugar
    6.9 percent target mRNA inhibition
    19282453
    SM0120
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    1,3,5,7,8,9,11,13,15,17,19,22 * 2,4,6,10,12,14,16,18,20,21
    1 * 18
    Sugar
    Sugar
    5.3 percent target mRNA inhibition
    19282453
    SM0163
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGC
    2-Deoxy* Locked nucleic acid
    Altritol nucleic acid
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,22 * 20,21
    1,2
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0164
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGC
    2-Deoxy* Locked nucleic acid
    Altritol nucleic acid
    1,2,4,5,7,8,10,11,13,14,16,17,19,22 * 3,6,9,12,15,18,20,21
    1,2
    Sugar
    Sugar
    4.4 percent target mRNA inhibition
    19282453
    SM0165
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGC
    2-Deoxy* Locked nucleic acid
    Altritol nucleic acid
    1,3,5,7,8,9,11,13,15,17,19,22 * 2,4,6,10,12,14,16,18,20,21
    1,2
    Sugar
    Sugar
    3.8 percent target mRNA inhibition
    19282453
    SM0208
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    Altritol nucleic acid
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,22 * 20,21
    20,21
    Sugar
    Sugar
    39.1 percent target mRNA inhibition
    19282453
    SM0209
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    Altritol nucleic acid
    1,2,4,5,7,8,10,11,13,14,16,17,19,22 * 3,6,9,12,15,18,20,21
    20,21
    Sugar
    Sugar
    59.5 percent target mRNA inhibition
    19282453
    SM0210
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    Altritol nucleic acid
    1,3,5,7,8,9,11,13,15,17,19,22 * 2,4,6,10,12,14,16,18,20,21
    20,21
    Sugar
    Sugar
    25.3 percent target mRNA inhibition
    19282453
    SM0253
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    Altritol nucleic acid
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,22 * 20,21
    5,8,11,14,17,20
    Sugar
    Sugar
    11.4 percent target mRNA inhibition
    19282453
    SM0254
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    Altritol nucleic acid
    1,2,4,5,7,8,10,11,13,14,16,17,19,22 * 3,6,9,12,15,18,20,21
    5,8,11,14,17,20
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0255
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    Altritol nucleic acid
    1,3,5,7,8,9,11,13,15,17,19,22 * 2,4,6,10,12,14,16,18,20,21
    5,8,11,14,17,20
    Sugar
    Sugar
    6.2 percent target mRNA inhibition
    19282453
    SM0298
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    Altritol nucleic acid
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,22 * 20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    22.8 percent target mRNA inhibition
    19282453
    SM0299
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    Altritol nucleic acid
    1,2,4,5,7,8,10,11,13,14,16,17,19,22 * 3,6,9,12,15,18,20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    22.6 percent target mRNA inhibition
    19282453
    SM0300
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    Altritol nucleic acid
    1,3,5,7,8,9,11,13,15,17,19,22 * 2,4,6,10,12,14,16,18,20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0343
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGT
    2-Deoxy* Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,22 * 20,21
    18,19,20 * 21
    Sugar
    Sugar
    2.7 percent target mRNA inhibition
    19282453
    SM0344
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGT
    2-Deoxy* Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    1,2,4,5,7,8,10,11,13,14,16,17,19,22 * 3,6,9,12,15,18,20,21
    18,19,20 * 21
    Sugar
    Sugar
    15.3 percent target mRNA inhibition
    19282453
    SM0345
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGT
    2-Deoxy* Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    1,3,5,7,8,9,11,13,15,17,19,22 * 2,4,6,10,12,14,16,18,20,21
    18,19,20 * 21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0389
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGT
    2-Deoxy* Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    1,2,4,5,7,8,10,11,13,14,16,17,19,22 * 3,6,9,12,15,18,20,21
    2,18,19,20 * 21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453