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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
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  • Reference
    • Total number of Results for 2-Fluoro* 2-O-Methyl* 5-Phosphate are 2
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2294
    AAGUAAGGACCAGAGACAA
    UUGUCUCUGGUCCUUACUU
    2-Fluoro* 2-O-Methyl* 5-Phosphate
    2-O-Methyl* 2-Fluoro* 5-Phosphate
    1,3,5,7,9,11,13,15,17,19 * 2,4,6,8,10,12,14,16,18 * 1
    1,3,5,7,9,11,13,15,17,19 * 2,4,6,8,10,12,14,16,18 * 1
    Sugar
    Sugar; Sugar; Phosphate
    75 percent target mRNA inhibition ( IC-50 = 0.068 nM)
    15715458
    SM2297
    GGGUAAAUACAUUCUUCAU
    AUGAAGAAUGUAUUUACCC
    2-Fluoro* 2-O-Methyl* 5-Phosphate
    2-O-Methyl* 2-Fluoro* 5-Phosphate
    1,3,5,7,9,11,13,15,17,19 * 2,4,6,8,10,12,14,16,18 * 1
    1,3,5,7,9,11,13,15,17,19 * 2,4,6,8,10,12,14,16,18 * 1
    Sugar; Sugar; Phosphate
    Sugar; Sugar; Phosphate
    83 percent target mRNA inhibition
    15715458