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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for Locked nucleic acid* Small internally segmented RNA are 5
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM2911	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid* Small internally segmented RNA Locked nucleic acid	3,9,13,15,20,21 * 14 20,21	Sugar Sugar	High target mRNA inhibition efficacy	21687525
SM2919	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid* Small internally segmented RNA Locked nucleic acid	3,9,13,15,20,21 * 14 20,21	Sugar Sugar	High target mRNA inhibition efficacy	21687525
SM2927	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid* Small internally segmented RNA Locked nucleic acid	3,9,13,15,20,21 * 14 20,21	Sugar Sugar	High target mRNA inhibition efficacy	21687525
SM2935	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid* Small internally segmented RNA Locked nucleic acid	3,9,13,15,20,21 * 14 20,21	Sugar Sugar	High target mRNA inhibition efficacy	21687525
SM3009	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid* Small internally segmented RNA Locked nucleic acid	3,9,13,15,20,21 * 10 3,6,14,18,20,21	Sugar; Phosphate Sugar	63 percent target mRNA inhibition	22287630