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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for Locked nucleic acid are 409
    Results from 375 - 400
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM3344
    AGACGAGCUGAGCGAGAAGTT
    TTUCUGCUCGACUCGCUCUUC
    Locked nucleic acid
    Locked nucleic acid
    1
    21
    Sugar
    Sugar
    NA
    12834349
    SM3345
    AGACGAGCUGAGCGAGAAGTT
    TTUCUGCUCGACUCGCUCUUC
    Locked nucleic acid
    Locked nucleic acid
    1,8,13,21
    1,7,18,21
    Sugar
    Sugar
    NA
    12834349
    SM3346
    AGACGAGCUGAGCGAGAAGTT
    TTUCUGCUCGACUCGCUCUUC
    Locked nucleic acid
    Locked nucleic acid
    1,21
    1,21
    Sugar
    Sugar
    NA
    12834349
    SM3347
    AGACGAGCUGAGCGAGAAGTT
    TTUCUGCUCGACUCGCUCUUC
    Locked nucleic acid
    Locked nucleic acid
    8,13
    7,18
    Sugar
    Sugar
    NA
    12834349
    SM3348
    AGACGAGCUGAGCGAGAAGTT
    TTUCUGCUCGACUCGCUCUUC
    Locked nucleic acid
    Locked nucleic acid
    4,13
    4,18
    Sugar
    Sugar
    NA
    12834349
    SM3349
    AGACGAGCUGAGCGAGAAGTT
    TTUCUGCUCGACUCGCUCUUC
    Locked nucleic acid
    Locked nucleic acid
    5,6,17,18
    4,6,16,18
    Sugar
    Sugar
    NA
    12834349
    SM4680
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    Locked nucleic acid
    1,20,21
    0
    Sugar
    Sugar
    80 percent target mRNA inhibition
    EP2548962A1
    SM4681
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    Locked nucleic acid
    1,20,21
    20,21
    Sugar
    Sugar
    70 percent target mRNA inhibition
    EP2548962A1
    SM4682
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    Locked nucleic acid
    1,2,13,14
    9,10,19,20
    Sugar
    Sugar
    60 percent target mRNA inhibition
    EP2548962A1
    SM4683
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    0
    1,2,13,14
    0
    Sugar
    0
    80 percent target mRNA inhibition
    EP2548962A1
    SM4684
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    Locked nucleic acid
    1,2,10,14
    11,12,19,20
    Sugar
    Sugar
    10 percent target mRNA inhibition
    EP2548962A1
    SM4685
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    0
    1,2,10,14
    0
    Sugar
    0
    69 percent target mRNA inhibition
    EP2548962A1
    SM4686
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    Locked nucleic acid
    1,2
    2 * 1
    Sugar
    Sugar
    70 percent target mRNA inhibition
    EP2548962A1
    SM4687
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    Locked nucleic acid
    1,2
    0
    Sugar
    Sugar
    72 percent target mRNA inhibition
    EP2548962A1
    SM4689
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    0
    1,20,21
    0
    Sugar
    0
    0 percent target mRNA inhibition
    EP2548962A1
    SM4690
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    Locked nucleic acid
    1,20,21
    20,21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    EP2548962A1
    SM4691
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    Locked nucleic acid
    1,2,13,14
    9,10,19,20
    Sugar
    Sugar
    0 percent target mRNA inhibition
    EP2548962A1
    SM4692
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    0
    1,2,13,14
    0
    Sugar
    0
    0 percent target mRNA inhibition
    EP2548962A1
    SM4693
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    Locked nucleic acid
    1,2,10,14
    11,12,19,20
    Sugar
    Sugar
    0 percent target mRNA inhibition
    EP2548962A1
    SM4694
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    0
    1,2,10,14
    0
    Sugar
    0
    0 percent target mRNA inhibition
    EP2548962A1
    SM4695
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    Locked nucleic acid
    1,2
    2 * 1
    Sugar
    Sugar
    0 percent target mRNA inhibition
    EP2548962A1
    SM4696
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    0
    1,2
    0
    Sugar
    0
    0 percent target mRNA inhibition
    EP2548962A1
    SM4712
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    Locked nucleic acid
    20,21
    1,20, 21
    Sugar
    Sugar
    14 percent target mRNA inhibition
    EP2548962A1
    SM4717
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    Locked nucleic acid
    20,21
    1,20, 21
    Sugar
    Sugar
    44 percent target mRNA inhibition
    EP2548962A1
    SM4723
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid
    2-Deoxy
    20,21
    20,21
    Sugar
    Sugar
    96 percent target mRNA inhibition
    US 8653252 B2