SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM4724 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
Locked nucleic acid Locked nucleic acid |
20,21 20,21 |
Sugar Sugar |
92 percent target mRNA inhibition | US 8653252 B2 |
SM4725 |
CUUACGCUGAGUACUUCGATT TCGAAGUACUCAGCGUAAGTT |
Locked nucleic acid Locked nucleic acid |
20,21 1,20,21 |
Sugar Sugar |
27 percent target mRNA inhibition | US 8653252 B2 |
SM4734 |
AUCUGAAGAAGGAGAAAAATT UUUUUCUCCUUCUUCAGAUTT |
Locked nucleic acid Locked nucleic acid |
20,21 20,21 |
Sugar Sugar |
93 percent target mRNA inhibition | US 8653252 B2 |
SM4735 |
AUCUGAAGAAGGAGAAAAATT UUUUUCUCCUUCUUCAGAUTT |
Locked nucleic acid Locked nucleic acid |
1,20,21 20,21 |
Sugar Sugar |
95 percent target mRNA inhibition | US 8653252 B2 |
SM4737 |
AUCUGAAGAAGGAGAAAAATT TUUUUCUCCUUCUUCAGAUTT |
Locked nucleic acid Locked nucleic acid |
20,21 1,20,21 |
Sugar Sugar |
63 percent target mRNA inhibition | US 8653252 B2 |
SM4738 |
AUCUGAAGAAGGAGAAAAATT TUUUUCUCCUUCUUCAGAUTT |
Locked nucleic acid Locked nucleic acid |
1,20,21 1,20,21 |
Sugar Sugar |
75 percent target mRNA inhibition | US 8653252 B2 |
SM4742 |
TGAGAGAAAGCACAGAAAATT UUUUCUGUGCUUUCUCUCATT |
Locked nucleic acid 2-Deoxy |
1,20,21 20,21 |
Sugar Sugar |
70 percent target mRNA inhibition | US 8653252 B2 |
SM4743 |
TGAGAGAAAGCACAGAAAATT UGAGAGAAAGCACAGAAAATT |
Locked nucleic acid 2-Deoxy |
1,3,5,9,12,14,17,20,21 20,21 |
Sugar Sugar |
64 percent target mRNA inhibition | US 8653252 B2 |
SM4745 |
TGAGAGAAAGCACAGAAAATT TUUUCUGUGCUUUCUCUCATT |
Locked nucleic acid Locked nucleic acid |
1,20,21 1,20,21 |
Sugar Sugar |
72 percent target mRNA inhibition | US 8653252 B2 |