SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM4373 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine 2-Deoxythymidine |
1 * 2 * 20,21 20,21 |
Phosphate ; Base ; Sugar Sugar |
43 percent target mRNA inhibition | 25699137 |
SM4375 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine 2-Deoxythymidine |
7 * 8 * 20,21 20,21 |
Phosphate ; Base ; Sugar Sugar |
86 percent target mRNA inhibition | 25699137 |
SM4377 |
CUUACGCUCUGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine 2-Deoxythymidine |
9 * 10 * 20,21 20,21 |
Phosphate ; Base ; Sugar Sugar |
50 percent target mRNA inhibition | 25699137 |
SM4380 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine 2-Deoxythymidine |
14 * 15 * 20,21 20,21 |
Phosphate ; Base ; Sugar Sugar |
67 percent target mRNA inhibition | 25699137 |
SM4388 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine 2-Deoxythymidine |
1 * 2 * 20,21 20,21 |
Phosphate ; Base ; Sugar Sugar |
85 percent target mRNA inhibition | 25699137 |
SM4390 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine 2-Deoxythymidine |
7 * 8 * 20,21 20,21 |
Phosphate ; Base ; Sugar Sugar |
95 percent target mRNA inhibition | 25699137 |
SM4392 |
CUUACGCUCUGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine 2-Deoxythymidine |
9 * 10 * 20,21 20,21 |
Phosphate ; Base ; Sugar Sugar |
90 percent target mRNA inhibition | 25699137 |
SM4395 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine 2-Deoxythymidine |
14 * 15 * 20,21 20,21 |
Phosphate ; Base ; Sugar Sugar |
96 percent target mRNA inhibition | 25699137 |
SM4402 |
GUGAAGUCAACAUGCCUGCTT GCAGGCAUGUUGACUUCACTT |
Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine 2-Deoxythymidine |
16 * 17 * 20,21 20,21 |
Phosphate ; Base ; Sugar Sugar |
85 percent target mRNA inhibition | 25699137 |
SM4409 |
GUGAAGUCAACAUGCCUGCTT GCAGGCAUGUUGACUUCACTT |
Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine 2-Deoxythymidine |
16 * 17 * 20,21 20,21 |
Phosphate ; Base ; Sugar Sugar |
83 percent target mRNA inhibition | 25699137 |