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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 1,2,18,19 are 8
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM2276	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	4-Thioribose 0	1,2,18,19 0	Sugar 0	IC-50 = 0.28 nM for target mRNA	16509579
SM2278	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	4-Thioribose Phosphorothioate	1,2,18,19 2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18	Sugar Phosphate	IC-50 = 1.4 nM for target mRNA	16509579
SM2280	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	4-Thioribose 4-Thioribose	1,2,18,19 1,2,18,19	Sugar Sugar	IC-50 = 0.21 nM for target mRNA	16509579
SM2286	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	4-Thioribose 4-Thioribose* 2-O-Methyl	1,2,18,19 1,2 * 17,18,19	Sugar Sugar	IC-50 = 0.15 nM for target mRNA	16509579
SM3287	GUAUUGACAGCUAUUCGAATT UUCGAAUAGCUGUCAAUACTT	Altritol nucleic acid 0	1,2,18,19 0	Sugar 0	53 percent target mRNA inhibition	17264131
SM4902	CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT	4-Thioribose 0	1,2,18,19 0	Sugar 0	95.3 percent target mRNA inhibition	17924376
SM4921	CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT	4-Thioribose 4-Thioribose	1,2,18,19 1,2,18,19	Sugar Sugar	85.3 percent target mRNA inhibition	17924376
SM4922	CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT	4-Thioribose 4-Thioribose	1,2,18,19 18,19	Sugar Sugar	92.1 percent target mRNA inhibition	17924376