| SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
|---|
| SM4220 |
UCGGGAAAUUUCUCUAUUATT
UAAUAGAGAAAUUUCCCGATT |
L-isonucleoside thymidine* 2-Deoxythymidine
2-Deoxythymidine |
1 * 20,21
20,21 |
Sugar ; Sugar
Sugar |
92 percent target mRNA inhibition | 22895883 |
| SM4226 |
UCGGGAAAUUUCUCUAUUATT
UAAUAGAGAAAUUUCCCGATT |
L-isonucleoside thymidine* 2-Deoxythymidine
2-Deoxythymidine |
1 * 20,21
20,21 |
Sugar ; Sugar
Sugar |
13 percent target mRNA inhibition | 22895883 |
| SM4372 |
CUUACGCUGAGUACUUCGATT
UCGAAGUACUCAGCGUAAGTT |
Triazole-linked nucleic acid* 2-Deoxythymidine
2-Deoxythymidine |
1 * 20,21
20,21 |
Phosphate ; Sugar
Sugar |
80 percent target mRNA inhibition | 25699137 |
| SM4385 |
CUUACGCUGAGUACUUCGATT
UCGAAGUACUCAGCGUAAGTT |
2-Deoxythymidine* Cholesterol
2-Deoxythymidine |
1 * 20,21
20,21 |
Sugar ; Base
Sugar |
65 percent target mRNA inhibition | 25699137 |
| SM4387 |
CUUACGCUGAGUACUUCGATT
UCGAAGUACUCAGCGUAAGTT |
Triazole-linked nucleic acid* 2-Deoxythymidine
2-Deoxythymidine |
1 * 20,21
20,21 |
Phosphate ; Sugar
Sugar |
87 percent target mRNA inhibition | 25699137 |
| SM4400 |
CUUACGCUGAGUACUUCGATT
UCGAAGUACUCAGCGUAAGTT |
2-Deoxythymidine* Cholesterol
2-Deoxythymidine |
1 * 20,21
20,21 |
Sugar ; Base
Sugar |
90 percent target mRNA inhibition | 25699137 |
| SM4418 |
CUUACGCUGAGUACUUCGATT
UCGAAGUACUCAGCGUAAGTT |
2-Deoxythymidine* Cholesterol
2-Deoxythymidine |
1 * 20,21
20,21 |
Sugar ; Base
Sugar |
40 percent target mRNA inhibition | 25699137 |
| SM4422 |
CUUACGCUGAGUACUUCGATT
UCGAAGUACUCAGCGUAAGTT |
2-Deoxythymidine* Cholesterol
2-Deoxythymidine |
1 * 20,21
20,21 |
Sugar ; Base
Sugar |
60 percent target mRNA inhibition | 25699137 |
| SM4426 |
CUUACGCUGAGUACUUCGATT
UCGAAGUACUCAGCGUAAGTT |
2-Deoxythymidine* Cholesterol
2-Deoxythymidine |
1 * 20,21
20,21 |
Sugar ; Base
Sugar |
79 percent target mRNA inhibition | 25699137 |
| SM4435 |
CUUCUUCGUCGAGACCAUGTT
CAUGGUCUCGACGAAGAAGTT |
[1,1-Biphenyl]-3,5-dimethanol* 2-Deoxyribonucleotide
2-Deoxyribonucleotide |
1 * 20,21
20,21 |
Base
Base |
45 percent target mRNA inhibition | 21141919 |
| SM4436 |
CUUCUUCGUCGAGACCAUGTT
CAUGGUCUCGACGAAGAAGTT |
[3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* 2-Deoxyribonucleotide
2-Deoxyribonucleotide |
1 * 20,21
20,21 |
Base
Base |
25 percent target mRNA inhibition | 21141919 |
| SM4440 |
UUUCACUACUCCUACGAGCTT
GCUCGUAGGAGUAGUGAAATT |
[3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* [3-(hydroxymethyl)phenyl]methanol
[3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* 1,3-Benzenedimethanol |
1 * 20,21
20,21 |
Base
Base |
67 percent target mRNA inhibition | 21141919 |
| SM4441 |
UUUCACUACUCCUACGAGCTT
GCUCGUAGGAGUAGUGAAATT |
[3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* [3-(hydroxymethyl)phenyl]methanol
[3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol |
1 * 20,21
20,21 |
Base
Base |
43 percent target mRNA inhibition | 21141919 |
| SM4463 |
UCCUACAGCACAACAAAUGUG
CAUUUGUUGUGCUGUAGGATT |
Palmitic acid* 2-Deoxyribonucleotide
2-Deoxyribonucleotide |
1 * 20,21
20,21 |
Phosphate; Sugar
Sugar |
90 percent target mRNA inhibition | 21985606 |
| SM4469 |
UCCUACAGCACAACAAAUGUG
CAUUUGUUGUGCUGUAGGAAG |
Palmitic acid* 2-Deoxyribonucleotide
2-Deoxyribonucleotide |
1 * 20,21
20,21 |
Phosphate; Sugar
Sugar |
73 percent target mRNA inhibition | 21985606 |
| SM4475 |
UCCUACAGCACAACAAAUGUG
CAUUUGUUGUGCUGUAGGAAG |
Palmitic acid* 2-Deoxyribonucleotide
2-Deoxyribonucleotide |
1 * 20,21
20,21 |
Phosphate; Sugar
Sugar |
18 percent target mRNA inhibition | 21985606 |
| SM4481 |
UCCUACAGCACAACAAAUGUG
CAUUUGUUGUGCUGUAGGAAG |
Palmitic acid* 2-Deoxyribonucleotide
2-Deoxyribonucleotide |
1 * 20,21
20,21 |
Phosphate; Sugar
Sugar |
6 percent target mRNA inhibition | 21985606 |
| SM4485 |
GCAGCACGACUUCUUCAAGTT
CUUGAAGAAGUCGUGCUGCTT |
5-Amino* 2-Deoxythymidine
2-Deoxythymidine |
1 * 20,21
1 * 20,21 |
Phosphate; Sugar
Phosphate; Sugar |
67 percent target mRNA inhibition | 12408823 |
| SM4487 |
GCAGCACGACUUCUUCAAGTT
CUUGAAGAAGUCGUGCUGCTT |
5-Amino* 2-Deoxythymidine
5-Amino* 2-Deoxythymidine |
1 * 20,21
1 * 20,21 |
Phosphate; Sugar
Phosphate; Sugar |
18 percent target mRNA inhibition | 12408823 |
| SM4488 |
GCAGCACGACUUCUUCAAGTT
CUUGAAGAAGUCGUGCUGCTT |
2-Deoxythymidine* Puromycin
2-Deoxythymidine |
1 * 20,21
20,21 |
Phosphate; Sugar
Sugar |
83 percent target mRNA inhibition | 12408823 |
| SM4490 |
GCAGCACGACUUCUUCAAGTT
CUUGAAGAAGUCGUGCUGCTT |
2-Deoxythymidine* Puromycin
2-Deoxythymidine* Puromycin |
1 * 20,21
20,21 * 21 |
Phosphate; Sugar
Sugar |
50 percent target mRNA inhibition | 12408823 |
| SM4491 |
GCAGCACGACUUCUUCAAGTT
CUUGAAGAAGUCGUGCUGCTT |
2-Deoxythymidine
2-Deoxythymidine* Biotin |
1 * 20,21
20,21 * 21 |
Phosphate; Sugar
Sugar |
61 percent target mRNA inhibition | 12408823 |
| SM4493 |
GCAGCACGACUUCUUCAAGTT
CUUGAAGAAGUCGUGCUGCTT |
5-Amino* 2-Deoxythymidine
2-Deoxythymidine |
1 * 20,21
1 * 20,21 |
Phosphate; Sugar
Phosphate; Sugar |
91 percent target mRNA inhibition | 12408823 |
| SM4495 |
GCAGCACGACUUCUUCAAGTT
CUUGAAGAAGUCGUGCUGCTT |
5-Amino* 2-Deoxythymidine
5-Amino* 2-Deoxythymidine |
1 * 20,21
1 * 20,21 |
Phosphate; Sugar
Phosphate; Sugar |
25 percent target mRNA inhibition | 12408823 |
| SM4496 |
GCAGCACGACUUCUUCAAGTT
CUUGAAGAAGUCGUGCUGCTT |
2-Deoxythymidine* Puromycin
2-Deoxythymidine |
1 * 20,21
20,21 |
Phosphate; Sugar
Sugar |
85 percent target mRNA inhibition | 12408823 |