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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 21 are 161
    Results from 150 - 175
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2928
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGUU
    UnLocked nucleic acid
    Unlocked nucleic acid
    21
    21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2929
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGCU
    UnLocked nucleic acid
    Unlocked nucleic acid * Locked nucleic acid
    21
    6 * 20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2936
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGUU
    UnLocked nucleic acid
    Unlocked nucleic acid
    21
    21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2937
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGCU
    UnLocked nucleic acid
    Unlocked nucleic acid * Locked nucleic acid
    21
    6 * 20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM3343
    AGACGAGCUGAGCGAGAAGTT
    TTUCUGCUCGACUCGCUCUUC
    Locked nucleic acid
    Locked nucleic acid
    21
    1
    Sugar
    Sugar
    NA
    12834349
    SM3359
    AGACGAGCUGAGCGAGAAGTT
    TTUCUGCUCGACUCGCUCUUC
    2-Deoxy-2-fluorouridine
    0
    21
    0
    Sugar
    0
    NA
    12834349
    SM3362
    AGACGAGCUGAGCGAGAAGTT
    TTUCUGCUCGACUCGCUCUUC
    2-Deoxy-2-fluorouridine
    2-Deoxy-2-fluorouridine
    21
    1
    Sugar
    Sugar
    NA
    12834349
    SM3370
    GAACUGUGUGUGAGAGGUCCU
    AGGACCUCUCACACACAGUUCGC
    Phosphorothioate
    Phosphorothioate* 2-O-Methyl
    21
    21,22 * 21,22
    Phosphate
    Phosphate; Sugar
    80 percent target mRNA inhibition
    21663557
    SM3371
    AGCUAGUCGUAGUGGAUGCGU
    ACGCAUCCACUACGACUAGCUCGC
    Phosphorothioate
    Phosphorothioate* 2-O-Methyl
    21
    22,23 * 22,23
    Phosphate
    Phosphate; Sugar
    NA
    21663557
    SM3390
    GGACCACCGCAUCUCUACATT
    GGACCACCGCAUCUCUACATT
    Galactose
    0
    21
    0
    Sugar
    0
    NA
    20704260
    SM3391
    GGACCACCGCAUCUCUACATT
    GGACCACCGCAUCUCUACATT
    Galactose
    Galactose
    21
    1
    Sugar
    Sugar
    NA
    20704260