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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 15653644 are 44
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM3045
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    20,21
    0
    Sugar
    93 percent target mRNA inhibition
    15653644
    SM3046
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid
    0
    20,21
    0
    Sugar
    0
    97 percent target mRNA inhibition
    15653644
    SM3047
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    93 percent target mRNA inhibition
    15653644
    SM3048
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid* Methylcytosine
    0
    1,20,22 * 1
    0
    Sugar; Base
    0
    97 percent target mRNA inhibition
    15653644
    SM3049
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid* Methylcytosine
    Locked nucleic acid
    1,20,22 * 1
    20,21
    Sugar; Base
    Sugar
    93 percent target mRNA inhibition
    15653644
    SM3050
    CTTACGCTGAGTACTTCGATT
    UCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid* Methylcytosine
    0
    1,2,3,8,12,15,16,20,21 * 1
    0
    Sugar; Base
    0
    81 percent target mRNA inhibition
    15653644
    SM3051
    CTTACGCTGAGTACTTCGATT
    UCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid* Methylcytosine
    Locked nucleic acid
    1,2,3,8,12,15,16,20,21 * 1
    20,21
    Sugar; Base
    0
    73 percent target mRNA inhibition
    15653644
    SM3052
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    1,20,21
    0
    Sugar
    57 percent target mRNA inhibition
    15653644
    SM3053
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid
    Locked nucleic acid
    20,21
    1,20,21
    Sugar
    Sugar
    27 percent target mRNA inhibition
    15653644
    SM3054
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid* Methylcytosine
    Locked nucleic acid
    1,20,22 * 1
    1,20,21
    Sugar; Base
    Sugar
    35 percent target mRNA inhibition
    15653644
    SM3055
    CUUACGCUGAGUACUUCGATT
    TCGAAGTACTCAGCGTAAGTT
    0
    Locked nucleic acid
    0
    1,7,10,16,20,21
    0
    Sugar
    19 percent target mRNA inhibition
    15653644
    SM3056
    AUCUGAAGAAGGAGAAAAATT
    UUUUUCUCCUUCUUCAGAUTT
    0
    Locked nucleic acid
    0
    20,21
    0
    Sugar
    90 percent target mRNA inhibition
    15653644
    SM3057
    AUCUGAAGAAGGAGAAAAATT
    UUUUUCUCCUUCUUCAGAUTT
    Locked nucleic acid
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    93 percent target mRNA inhibition
    15653644
    SM3058
    AUCUGAAGAAGGAGAAAAATT
    UUUUUCUCCUUCUUCAGAUTT
    Locked nucleic acid
    Locked nucleic acid
    1,20,21
    20,21
    Sugar
    Sugar
    93 percent target mRNA inhibition
    15653644
    SM3059
    AUCUGAAGAAGGAGAAAAATT
    TUUUUCUCCUUCUUCAGAUTT
    0
    Locked nucleic acid
    0
    1,20,21
    0
    Sugar
    22 percent target mRNA inhibition
    15653644
    SM3060
    AUCUGAAGAAGGAGAAAAATT
    TUUUUCUCCUUCUUCAGAUTT
    Locked nucleic acid
    Locked nucleic acid
    20,21
    1,20,21
    Sugar
    Sugar
    52 percent target mRNA inhibition
    15653644
    SM3061
    AUCUGAAGAAGGAGAAAAATT
    TUUUUCUCCUUCUUCAGAUTT
    Locked nucleic acid
    Locked nucleic acid
    1,20,21
    1,20,21
    Sugar
    Sugar
    65 percent target mRNA inhibition
    15653644
    SM3062
    TGAGAGAAAGCACAGAAAATT
    UUUUCUGUGCUUUCUCUCATT
    Locked nucleic acid
    0
    1,20,21
    0
    Sugar
    0
    74 percent target mRNA inhibition
    15653644
    SM3063
    TGAGAGAAAGCACAGAAAATT
    UUUUCUGUGCUUUCUCUCATT
    Locked nucleic acid
    0
    1,3,5,9,12,14,17,20,21
    0
    Sugar
    0
    68 percent target mRNA inhibition
    15653644
    SM3064
    UGAGAGAAAGCACAGAAAATT
    TUUUCUGUGCUUUCUCUCATT
    0
    Locked nucleic acid
    0
    1,20,21
    0
    Sugar
    45 percent target mRNA inhibition
    15653644
    SM3065
    TGAGAGAAAGCACAGAAAATT
    TUUUCUGUGCUUUCUCUCATT
    Locked nucleic acid
    Locked nucleic acid
    1,20,21
    1,20,21
    Sugar
    Sugar
    67 percent target mRNA inhibition
    15653644
    SM3066
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    Locked nucleic acid
    0
    1,20,21
    0
    Sugar
    0
    82 percent target mRNA inhibition
    15653644
    SM3067
    TCCAGAACAAAGGAAACGGTT
    CCGUUUCCUUUGUUCUGGATT
    Locked nucleic acid
    0
    1,20,21
    0
    Sugar
    0
    50 percent target mRNA inhibition
    15653644
    SM3068
    GGAUGAGGAAGGCAAUUUATT
    UAAAUUGCCUUCCUCAUCCTT
    Locked nucleic acid
    Locked nucleic acid
    1,20,21
    20,21
    Sugar
    Sugar
    50 percent target mRNA inhibition
    15653644
    SM3069
    CUGGUACGAUUUCGGUGAUTT
    AGCACCGAAAUCGUACCAGTT
    Locked nucleic acid* Methylcytosine
    Locked nucleic acid
    1,20,21 * 1
    20,21
    Sugar; Base
    Sugar
    93 percent target mRNA inhibition
    15653644