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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 15974578 are 73
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4298
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21
    0
    Sugar
    30 percent target mRNA inhibition
    15974578
    SM4299
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-Methyl
    0
    1,2,3
    0
    Sugar
    19 percent target mRNA inhibition
    15974578
    SM4300
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-Methyl
    0
    3,4,5
    0
    Sugar
    26 percent target mRNA inhibition
    15974578
    SM4301
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-Methyl
    0
    6,7,8
    0
    Sugar
    50 percent target mRNA inhibition
    15974578
    SM4302
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-Methyl
    0
    9,10,11
    0
    Sugar
    49 percent target mRNA inhibition
    15974578
    SM4303
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-Methyl
    0
    12,13,14
    0
    Sugar
    12 percent target mRNA inhibition
    15974578
    SM4304
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-Methyl
    0
    15,16,17
    0
    Sugar
    52 percent target mRNA inhibition
    15974578
    SM4305
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-Methyl
    0
    18,19,20
    0
    Sugar
    57 percent target mRNA inhibition
    15974578
    SM4306
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-Methyl
    0
    1,2,3
    0
    Sugar
    52 percent target mRNA inhibition
    15974578
    SM4307
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-Methyl
    0
    3,4,5
    0
    Sugar
    75 percent target mRNA inhibition
    15974578
    SM4308
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-Methyl
    0
    6,7,8
    0
    Sugar
    77 percent target mRNA inhibition
    15974578
    SM4309
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-Methyl
    0
    9,10,11
    0
    Sugar
    82 percent target mRNA inhibition
    15974578
    SM4310
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-Methyl
    0
    12,13,14
    0
    Sugar
    47 percent target mRNA inhibition
    15974578
    SM4311
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-Methyl
    0
    15,16,17
    0
    Sugar
    78 percent target mRNA inhibition
    15974578
    SM4312
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-Methyl
    0
    18,19,20
    0
    Sugar
    82 percent target mRNA inhibition
    15974578
    SM4313
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-Methylribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 1,2,3
    0
    Sugar ; Phosphate
    20 percent target mRNA inhibition
    15974578
    SM4314
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-Methylribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 3,4,5
    0
    Sugar ; Phosphate
    28 percent target mRNA inhibition
    15974578
    SM4315
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-Methylribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 6,7,8
    0
    Sugar ; Phosphate
    45 percent target mRNA inhibition
    15974578
    SM4316
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-Methylribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 9,10,11
    0
    Sugar ; Phosphate
    55 percent target mRNA inhibition
    15974578
    SM4317
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-Methylribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 12,13,14
    0
    Sugar ; Phosphate
    30 percent target mRNA inhibition
    15974578
    SM4318
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-Methylribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 15,16,17
    0
    Sugar ; Phosphate
    38 percent target mRNA inhibition
    15974578
    SM4319
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-Methylribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 18,19,20
    0
    Sugar ; Phosphate
    42 percent target mRNA inhibition
    15974578
    SM4320
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-Methylribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 1,2,3
    0
    Sugar ; Phosphate
    40 percent target mRNA inhibition
    15974578
    SM4321
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-Methylribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 3,4,5
    0
    Sugar ; Phosphate
    47 percent target mRNA inhibition
    15974578
    SM4322
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-Methylribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 6,7,8
    0
    Sugar ; Phosphate
    69 percent target mRNA inhibition
    15974578