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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 16598842 are 23
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2240
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    Phosphorothioate
    Phosphorothioate
    2,3,4
    2,3,4
    Phosphate
    Phosphate
    75 percent target mRNA inhibition
    16598842
    SM2241
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    Phosphorothioate
    Phosphorothioate
    17,18,19
    17,18,19
    Phosphate
    Phosphate
    79 percent target mRNA inhibition
    16598842
    SM2242
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    Phosphorothioate
    Phosphorothioate
    2,3,4,17,18,19
    2,3,4,17,18,19
    Phosphate
    Phosphate
    78 percent target mRNA inhibition
    16598842
    SM2243
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    1,2,3
    1,2,3
    Sugar
    Sugar
    60 percent target mRNA inhibition
    16598842
    SM2244
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    17,18,19
    17,18,19
    Sugar
    Sugar
    73 percent target mRNA inhibition
    16598842
    SM2245
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    1,2,3,17,18,19
    1,2,3,17,18,19
    Sugar
    Sugar
    76 percent target mRNA inhibition
    16598842
    SM2246
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    1,2,3,6,7,8,12,13,14,17,18,19
    1,2,3,6,7,8,12,13,14,17,18,19
    Sugar
    Sugar
    45 percent target mRNA inhibition
    16598842
    SM2247
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    4,5,9,10,11,15,16
    1,2,3,6,7,8,12,13,14,17,18,19
    Sugar
    Sugar
    38 percent target mRNA inhibition
    16598842
    SM2248
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    1,3,5,7,9,11,13,15,17,19
    1,3,5,7,9,11,13,15,17,19
    Sugar
    Sugar
    75 percent target mRNA inhibition
    16598842
    SM2249
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    1,3,5,7,9,11,13,15,17,19
    2,4,6,8,10,12,14,16,18,
    Sugar
    Sugar
    65 percent target mRNA inhibition
    16598842
    SM2250
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18,
    1,3,5,7,9,11,13,15,17,19
    Sugar
    Sugar
    83 percent target mRNA inhibition
    16598842
    SM2251
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    2,4,6,8,10,12,14,16,18
    Sugar
    Sugar
    61 percent target mRNA inhibition
    16598842
    SM2252
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    Phosphorothioate
    Phosphorothioate
    2,4,6,8,10,12,14,16,18
    2,4,6,8,10,12,14,16,18
    Phosphate
    Phosphate
    74 percent target mRNA inhibition
    16598842
    SM2253
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    18,19
    Sugar
    Sugar
    77 percent target mRNA inhibition
    16598842
    SM2254
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    Phosphorothioate
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    Sugar
    Phosphate
    76 percent target mRNA inhibition
    16598842
    SM2255
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    1,7,13,14,15,16,17,18,19
    Sugar
    Sugar
    29 percent target mRNA inhibition
    16598842
    SM2256
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-Fluoro
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    1,7,13,14,15,16,17,18,19
    Sugar
    Sugar
    71 percent target mRNA inhibition
    16598842
    SM2257
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    8,9,12,14,15,16,17,18
    1,7,9,10,13,14,15,16,17,18,19
    Sugar
    Sugar
    37 percent target mRNA inhibition
    16598842
    SM2258
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl* Phosphorothioate
    2-O-Methyl
    8,9,12,14,15,17,18 * 19
    14,15,17,18,19
    Sugar; Phosphate
    Sugar
    84 percent target mRNA inhibition
    16598842
    SM2259
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl* Phosphorothioate
    Phosphorothioate* 2-O-Methyl
    8,9,12,14,15,16,17,18 * 2,3,4,5,6,7
    2,3,4,5,6,7,8,9,10,11,12,13 *14,15,17,18,19
    Sugar; Phosphate
    Phosphate; Sugar
    77 percent target mRNA inhibition
    16598842
    SM2260
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    8,9,12,14,15,16,17,18
    1,7,13,14,15,16,17,18,19
    Sugar
    Sugar
    53 percent target mRNA inhibition
    16598842
    SM2261
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    8,9,12,14,15,16,17,18
    1,7,13,14,15,16,17,18,19
    Sugar
    Sugar
    74 percent target mRNA inhibition
    16598842
    SM2262
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-Fluoro* Inverted DeoxyThymidine
    8,9,12,14,15,16,17,18
    1,7,9,10,13,14,15,16,17,18,19 *21
    Sugar
    Sugar
    77 percent target mRNA inhibition
    16598842