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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 19282453 are 2160
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM0001
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2-O-Methyl
    18
    2
    Sugar
    Sugar
    69.5 percent target mRNA inhibition
    19282453
    SM0002
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Guanidinoethyl
    2-O-Methyl
    18
    2
    Sugar
    Sugar
    76.8 percent target mRNA inhibition
    19282453
    SM0003
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    2-O-Methyl
    2,8,14,17
    2
    Sugar
    Sugar
    54.2 percent target mRNA inhibition
    19282453
    SM0004
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    2-O-Methyl
    5,8,14,17,22
    2
    Sugar
    Sugar
    35.4 percent target mRNA inhibition
    19282453
    SM0005
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Altritol nucleic acid* 2-Deoxy
    2-O-Methyl
    1,2 * 22
    2
    Sugar
    Sugar
    81.4 percent target mRNA inhibition
    19282453
    SM0006
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Altritol nucleic acid* 2-Deoxy
    2-O-Methyl
    18,19 * 22
    2
    Sugar
    Sugar
    71.3 percent target mRNA inhibition
    19282453
    SM0007
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Altritol nucleic acid* 2-Deoxy
    2-O-Methyl
    5,8,11,14,17 * 22
    2
    Sugar
    Sugar
    25.7 percent target mRNA inhibition
    19282453
    SM0008
    GACGUAAACGGCCACAAGUUCU
    ACUUGUGGCCGUUUACGUCGC
    Altritol nucleic acid
    2-O-Methyl
    20,21
    2
    Sugar
    Sugar
    64.5 percent target mRNA inhibition
    19282453
    SM0009
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    2-O-Methyl
    19,20
    2
    Sugar
    Sugar
    57 percent target mRNA inhibition
    19282453
    SM0010
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid* 2-Deoxy
    2-O-Methyl
    1,2,3,18,19,20 * 21
    2
    Sugar
    Sugar
    84 percent target mRNA inhibition
    19282453
    SM0011
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid* 2-Deoxy
    2-O-Methyl
    5,8,11,14 * 21
    2
    Sugar
    Sugar
    38 percent target mRNA inhibition
    19282453
    SM0012
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid* 2-Deoxy
    2-O-Methyl
    5,8,11,14,19,20 * 21
    2
    Sugar
    Sugar
    44.7 percent target mRNA inhibition
    19282453
    SM0013
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethoxymethyl* 2-Deoxy
    2-O-Methyl
    19,20 * 21
    2
    Sugar
    Sugar
    79.7 percent target mRNA inhibition
    19282453
    SM0014
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethoxymethyl* 2-Deoxy
    2-O-Methyl
    3,5,9,19,20 * 21
    2
    Sugar
    Sugar
    49.8 percent target mRNA inhibition
    19282453
    SM0015
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    2-Aminopropoxymethyl* 2-Deoxy
    2-O-Methyl
    19,20 * 21
    2
    Sugar
    Sugar
    80.6 percent target mRNA inhibition
    19282453
    SM0016
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    2-Aminopropoxymethyl* 2-Deoxy
    2-O-Methyl
    3,5,9,19,20 * 21
    2
    Sugar
    Sugar
    49.3 percent target mRNA inhibition
    19282453
    SM0017
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Oxetane-Locked nucleic acid
    2-O-Methyl
    16,18
    2
    Sugar
    Sugar
    81.2 percent target mRNA inhibition
    19282453
    SM0018
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Oxetane-Locked nucleic acid
    2-O-Methyl
    2,4
    2
    Sugar
    Sugar
    65.2 percent target mRNA inhibition
    19282453
    SM0019
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Fluoro* 2-O-Methyl
    2-O-Methyl
    1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
    2
    Sugar
    Sugar
    46.2 percent target mRNA inhibition
    19282453
    SM0020
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2-O-Methyl
    20
    2
    Sugar
    Sugar
    80 percent target mRNA inhibition
    19282453
    SM0021
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2-O-Methyl
    19
    2
    Sugar
    Sugar
    66.4 percent target mRNA inhibition
    19282453
    SM0022
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2-O-Methyl
    5,19,20
    2
    Sugar
    Sugar
    45.9 percent target mRNA inhibition
    19282453
    SM0023
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2-O-Methyl
    3,9,15,20,21
    2
    Sugar
    Sugar
    31 percent target mRNA inhibition
    19282453
    SM0024
    GACGUAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGC
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-O-Methyl
    19,20
    2
    Sugar
    Sugar
    74 percent target mRNA inhibition
    19282453
    SM0025
    GACGTAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGC
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-O-Methyl
    5,19,20
    2
    Sugar
    Sugar
    74.6 percent target mRNA inhibition
    19282453