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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 20610434 are 62
    Results from 50 - 75
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2829
    CUUACGCUGAGUACUUCGAAA
    UCGAAGUACUCAGCGUAAGUG
    2-O-Methyl* Phosphorothioate
    0
    9
    0
    Sugar; Phosphate
    0
    IC-50 = 0.129 nM for target mRNA
    20610434
    SM2830
    CUUACGCUGAGUACUUCGAAA
    UCGAAGUACUCAGCGUAAGUG
    2,4-Difluorotoluene
    0
    10
    0
    Base
    0
    IC-50 = 0.056 nM for target mRNA
    20610434
    SM2831
    CUUACGCUGAAGUACUUCGAAA
    UCGAAGUACUCAGCGUAAGUG
    Phosphorothioate* 2,4-Difluorotoluene
    0
    9 * 10
    0
    Phosphate; Base
    0
    IC-50 = 0.052 nM for target mRNA
    20610434
    SM2832
    GAACGUGAAUUGCUCAACATT
    UGUUGAGCAAUUCACGUUCTT
    2-O-Methyl* Phosphorothioate
    2-O-Methyl* Phosphorothioate
    4,6,10,11,13,14,15,18 * 20
    8,13 * 20
    Sugar; Phosphate
    Sugar; Phosphate
    IC-50 = 0.503 nM for target mRNA
    20610434
    SM2833
    GAACGUGAAUUGCUCAACATT
    UGUUGAGCAAUUCACGUUCTT
    2-O-Methyl* 2,4-Difluorotoluene* Phosphorothioate
    2-O-Methyl* Phosphorothioate
    4,6,10,11,13,14,15,18 * 9 *20
    8,13 * 20
    Sugar; Base; Phosphate
    Sugar; Phosphate
    IC-50 = 0.221 nM for target mRNA
    20610434
    SM2834
    GAACGUGAAUUGCUCAACATT
    UGUUGAGCAAUUCACGUUCTT
    2-O-Methyl* 2,4-Difluorotoluene* Phosphorothioate
    2-O-Methyl* Phosphorothioate
    4,6,11, 13,14,15,18 * 10 * 20
    8,13 * 20
    Sugar; Base; Phosphate
    Sugar; Phosphate
    IC-50 = 0.141 nM for target mRNA
    20610434
    SM2835
    GAACGUGAAUUGCUCAACATT
    UGUUGAGCAAUUCACGUUCTT
    2-O-Methyl* 2,4-Difluorotoluene* Phosphorothioate
    2-O-Methyl* Phosphorothioate
    4,6,10, 13,14,15,18 * 11 * 20
    8,13 * 20
    Sugar; Base; Phosphate
    Sugar; Phosphate
    IC-50 = 0.132 nM for target mRNA
    20610434
    SM2836
    GAACGUGAAUUGCUCAACATT
    UGUUGAGCAAUUCACGUUCTT
    2-O-Methyl* 2,4-Difluorotoluene* Phosphorothioate
    2-O-Methyl* Phosphorothioate
    4,6,10, 11,13,14,15,18 * 12 * 20
    8,13 * 20
    Sugar; Base; Phosphate
    Sugar; Phosphate
    IC-50 = 0.253 nM for target mRNA
    20610434
    SM2844
    AAGUAAGGACCAGAGACAATT
    UUGUCUCUGGUCCUUACUUTT
    2,4-difluorotoluene ribonucleotide
    0
    9
    0
    Base
    0
    IC-50 = 0.031 nM for target mRNA
    20610434
    SM2845
    AAGUAAGGACCAGAGACAATT
    UUGUCUCUGGUCCUUACUUTT
    2,4-difluorotoluene ribonucleotide
    0
    10
    0
    Base
    0
    IC-50 = 0.04 nM for target mRNA
    20610434
    SM2846
    AAGUAAGGACCAGAGACAATT
    UUGUCUCUGGUCCUUACUUTT
    2,4-difluorotoluene ribonucleotide
    0
    11
    0
    Base
    0
    IC-50 = 0.039 nM for target mRNA
    20610434
    SM2847
    AAGUAAGGACCAGAGACAATT
    UUGUCUCUGGUCCUUACUUTT
    2,4-difluorotoluene ribonucleotide
    0
    12
    0
    Base
    0
    IC-50 = 0.027 nM for target mRNA
    20610434