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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 21427169 are 3
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4955
    AUAAGGCUAUGAAGAGAUATT
    UAUCUCUUCAUAGCCUUAUUU
    Inverted abasic* 2-Deoxy* 2-Fluoro
    2-Fluoro* 2-O-Methyl
    1,21 * 1,3,4,5,6,9,11,12,13,14,15,16,17,19,20,21 * 2,7,8,10,18
    4,5,6,7,8,9,11,14,15,16,17,19 * 10,12,13,18,20,21
    Base; Sugar; Sugar
    Sugar
    High target mRNA inhibition efficacy
    21427169
    SM4956
    ACAACAGACUUUAAUGUAATT
    UUACAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Fluoro
    2-Fluoro* 2-O-Methyl
    1,21 * 1,3,4,6,7,8,13,14,16,18,19,20,21 * 2,5,9,10,11,12,15,17
    4,6,7,12,13,14,16,17,19 * 5,8,9,10,11,15,18,20,21
    Base; Sugar; Sugar
    Sugar
    NA
    21427169
    SM4957
    GUAUGACCGACUACGCGUATT
    UACGCGUAGUCGGUCAUACUU
    Inverted abasic* 2-Deoxy* 2-Fluoro
    2-Fluoro* 2-O-Methyl
    1,21 * 1,3,5,6,9,10,13,15,17,19,20,21 * 2,4,7,8,11,12,14,16,18,
    5,7,10,11,14,15,17,19 * 4,6,8,9,12,13,16,18,20,21
    Base; Sugar; Sugar
    Sugar
    NA
    21427169