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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 22287630 are 7
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM3009	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid* Small internally segmented RNA Locked nucleic acid	3,9,13,15,20,21 * 10 3,6,14,18,20,21	Sugar; Phosphate Sugar	63 percent target mRNA inhibition	22287630
SM3010	GACGUAAACGGCCACAAGUUT ACUUGUGGCCGUUUACGUCGT	0 Hexitol nucleic acid	0 8,14,18,19,20	0 Sugar	87 percent target mRNA inhibition	22287630
SM3011	GACGUAAACGGCCACAAGUUT ACUUGUGGCCGUUUACGUCGT	2-Aminoethoxymethyl 2-Aminoethoxymethyl	3,5,9,19,20 3,10,18,19	Sugar Sugar	0 percent target mRNA inhibition	22287630
SM3012	GACGUAAACGGCCACAAGUUCT ACUUGUGGCCGUUUACGUCGCU	Altritol nucleic acid Altritol nucleic acid	3,9,15,20,21 5,8,11,14,17,20	Sugar Sugar	84 percent target mRNA inhibition	22287630
SM3013	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	3,5,9,13,20,21 19,21	Sugar Sugar	91 percent target mRNA inhibition	22287630
SM3014	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGCU	0 O-Methyl	0 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,22	0 Sugar	75 percent target mRNA inhibition	22287630
SM3015	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Locked nucleic acid	20,21 20,21	Sugar Sugar	92 percent target mRNA inhibition	22287630