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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 22895883 are 12
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4219
    UCGGGAAAUUUCUCUAUUATT
    UAAUAGAGAAAUUUCCCGATT
    2-Deoxythymidine
    2-Deoxythymidine
    20,21
    20,21
    Sugar
    Sugar
    94 percent target mRNA inhibition
    22895883
    SM4220
    UCGGGAAAUUUCUCUAUUATT
    UAAUAGAGAAAUUUCCCGATT
    L-isonucleoside thymidine* 2-Deoxythymidine
    2-Deoxythymidine
    1 * 20,21
    20,21
    Sugar ; Sugar
    Sugar
    92 percent target mRNA inhibition
    22895883
    SM4221
    UCGGGAAAUUUCUCUAUUATT
    UAAUAGAGAAAUUUCCCGATT
    L-isonucleoside adenosine* 2-Deoxythymidine
    2-Deoxythymidine
    19 * 20,21
    20,21
    Sugar ; Sugar
    Sugar
    95 percent target mRNA inhibition
    22895883
    SM4222
    UCGGGAAAUUUCUCUAUUATT
    UAAUAGAGAAAUUUCCCGATT
    2-Deoxythymidine
    L-isonucleoside thymidine* 2-Deoxythymidine
    20,21
    4 * 20,21
    Sugar
    Sugar ; Sugar
    69 percent target mRNA inhibition
    22895883
    SM4223
    UCGGGAAAUUUCUCUAUUATT
    UAAUAGAGAAAUUUCCCGATT
    2-Deoxythymidine
    L-isonucleoside adenosine* 2-Deoxythymidine
    20,21
    19 * 20,21
    Sugar
    Sugar ; Sugar
    90 percent target mRNA inhibition
    22895883
    SM4224
    UCGGGAAAUUUCUCUAUUATT
    UAAUAGAGAAAUUUCCCGATT
    2-Deoxythymidine
    L-isonucleoside adenosine* 2-Deoxythymidine
    20,21
    2 * 20,21
    Sugar
    Sugar ; Sugar
    74 percent target mRNA inhibition
    22895883
    SM4225
    UCGGGAAAUUUCUCUAUUATT
    UAAUAGAGAAAUUUCCCGATT
    2-Deoxythymidine
    2-Deoxythymidine
    20,21
    20,21
    Sugar
    Sugar
    80 percent target mRNA inhibition
    22895883
    SM4226
    UCGGGAAAUUUCUCUAUUATT
    UAAUAGAGAAAUUUCCCGATT
    L-isonucleoside thymidine* 2-Deoxythymidine
    2-Deoxythymidine
    1 * 20,21
    20,21
    Sugar ; Sugar
    Sugar
    13 percent target mRNA inhibition
    22895883
    SM4227
    UCGGGAAAUUUCUCUAUUATT
    UAAUAGAGAAAUUUCCCGATT
    L-isonucleoside adenosine* 2-Deoxythymidine
    2-Deoxythymidine
    19 * 20,21
    20,21
    Sugar ; Sugar
    Sugar
    36 percent target mRNA inhibition
    22895883
    SM4228
    UCGGGAAAUUUCUCUAUUATT
    UAAUAGAGAAAUUUCCCGATT
    2-Deoxythymidine
    L-isonucleoside thymidine* 2-Deoxythymidine
    20,21
    4 * 20,21
    Sugar
    Sugar ; Sugar
    70 percent target mRNA inhibition
    22895883
    SM4229
    UCGGGAAAUUUCUCUAUUATT
    UAAUAGAGAAAUUUCCCGATT
    2-Deoxythymidine
    L-isonucleoside adenosine* 2-Deoxythymidine
    20,21
    19 * 20,21
    Sugar
    Sugar ; Sugar
    90 percent target mRNA inhibition
    22895883
    SM4230
    UCGGGAAAUUUCUCUAUUATT
    UAAUAGAGAAAUUUCCCGATT
    2-Deoxythymidine
    L-isonucleoside adenosine* 2-Deoxythymidine
    20,21
    2 * 20,21
    Sugar
    Sugar ; Sugar
    89 percent target mRNA inhibition
    22895883