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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for US 8653252 B2 are 26
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4720
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    2-Deoxy
    2-Deoxy
    20,21
    20,21
    Sugar
    Sugar
    95 percent target mRNA inhibition
    US 8653252 B2
    SM4721
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    2-Deoxy
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    92 percent target mRNA inhibition
    US 8653252 B2
    SM4722
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2-Deoxy
    Locked nucleic acid
    20,21
    1,20,21
    Sugar
    Sugar
    55 percent target mRNA inhibition
    US 8653252 B2
    SM4723
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid
    2-Deoxy
    20,21
    20,21
    Sugar
    Sugar
    96 percent target mRNA inhibition
    US 8653252 B2
    SM4724
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    92 percent target mRNA inhibition
    US 8653252 B2
    SM4725
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid
    Locked nucleic acid
    20,21
    1,20,21
    Sugar
    Sugar
    27 percent target mRNA inhibition
    US 8653252 B2
    SM4726
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    5-Methylcytosine* Locked nucleic acid
    2-Deoxy
    1 * 20,21
    20,21
    Sugar
    Sugar
    95 percent target mRNA inhibition
    US 8653252 B2
    SM4727
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    5-Methylcytosine* Locked nucleic acid
    Locked nucleic acid
    1 * 20,21
    20,21
    Sugar
    Sugar
    91 percent target mRNA inhibition
    US 8653252 B2
    SM4728
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    5-Methylcytosine* Locked nucleic acid
    Locked nucleic acid
    1 * 20,21
    1,20,21
    Sugar
    Sugar
    35 percent target mRNA inhibition
    US 8653252 B2
    SM4729
    CTTACGCTGAGTACTTCGATT
    UCGAAGUACUCAGCGUAAGTT
    5-Methylcytosine* Locked nucleic acid
    2-Deoxy
    1 * 2,3,8,12,15,16,20,21
    20,21
    Sugar
    Sugar
    80 percent target mRNA inhibition
    US 8653252 B2
    SM4730
    CTTACGCTGAGTACTTCGATT
    UCGAAGUACUCAGCGUAAGTT
    5-Methylcytosine* Locked nucleic acid
    Locked nucleic acid
    2 * 2,3,8,12,15,16,20,21
    20,21
    Sugar
    Sugar
    73 percent target mRNA inhibition
    US 8653252 B2
    SM4731
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2-Deoxy
    Locked nucleic acid
    20,21
    1,8,11,17,20,21
    Sugar
    Sugar
    15 percent target mRNA inhibition
    US 8653252 B2
    SM4732
    AUCUGAAGAAGGAGAAAAATT
    UUUUUCUCCUUCUUCAGAUTT
    2-Deoxy
    2-Deoxy
    20,21
    20,21
    Sugar
    Sugar
    95 percent target mRNA inhibition
    US 8653252 B2
    SM4733
    AUCUGAAGAAGGAGAAAAATT
    UUUUUCUCCUUCUUCAGAUTT
    2-Deoxy
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    93 percent target mRNA inhibition
    US 8653252 B2
    SM4734
    AUCUGAAGAAGGAGAAAAATT
    UUUUUCUCCUUCUUCAGAUTT
    Locked nucleic acid
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    93 percent target mRNA inhibition
    US 8653252 B2
    SM4735
    AUCUGAAGAAGGAGAAAAATT
    UUUUUCUCCUUCUUCAGAUTT
    Locked nucleic acid
    Locked nucleic acid
    1,20,21
    20,21
    Sugar
    Sugar
    95 percent target mRNA inhibition
    US 8653252 B2
    SM4736
    AUCUGAAGAAGGAGAAAAATT
    TUUUUCUCCUUCUUCAGAUTT
    2-Deoxy
    Locked nucleic acid
    20,21
    1,20,21
    Sugar
    Sugar
    45 percent target mRNA inhibition
    US 8653252 B2
    SM4737
    AUCUGAAGAAGGAGAAAAATT
    TUUUUCUCCUUCUUCAGAUTT
    Locked nucleic acid
    Locked nucleic acid
    20,21
    1,20,21
    Sugar
    Sugar
    63 percent target mRNA inhibition
    US 8653252 B2
    SM4738
    AUCUGAAGAAGGAGAAAAATT
    TUUUUCUCCUUCUUCAGAUTT
    Locked nucleic acid
    Locked nucleic acid
    1,20,21
    1,20,21
    Sugar
    Sugar
    75 percent target mRNA inhibition
    US 8653252 B2
    SM4739
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    2-Deoxy
    2-Deoxy
    20,21
    20,21
    Sugar
    Sugar
    96 percent target mRNA inhibition
    US 8653252 B2
    SM4740
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACTCAGCGUAAGTT
    2-Deoxy
    Locked nucleic acid
    20,21
    10,20,21
    Sugar
    Sugar
    52 percent target mRNA inhibition
    US 8653252 B2
    SM4741
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACTCAGCGUAAGTT
    2-Deoxy
    Locked nucleic acid
    20,21
    10,20,22
    Sugar
    Sugar
    93 percent target mRNA inhibition
    US 8653252 B2
    SM4742
    TGAGAGAAAGCACAGAAAATT
    UUUUCUGUGCUUUCUCUCATT
    Locked nucleic acid
    2-Deoxy
    1,20,21
    20,21
    Sugar
    Sugar
    70 percent target mRNA inhibition
    US 8653252 B2
    SM4743
    TGAGAGAAAGCACAGAAAATT
    UGAGAGAAAGCACAGAAAATT
    Locked nucleic acid
    2-Deoxy
    1,3,5,9,12,14,17,20,21
    20,21
    Sugar
    Sugar
    64 percent target mRNA inhibition
    US 8653252 B2
    SM4744
    UGAGAGAAAGCACAGAAAATT
    TUUUCUGUGCUUUCUCUCATT
    2-Deoxy
    Locked nucleic acid
    20,21
    1,20,21
    Sugar
    Sugar
    34 percent target mRNA inhibition
    US 8653252 B2