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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-Deoxy-2-Fluoro are 171
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2547
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    0
    2-Deoxy-2-Fluoro
    0
    1,9,10,12,15,16,19
    0
    Sugar
    22 percent target mRNA inhibition
    17511001
    SM2548
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    0
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    0
    Sugar
    55 percent target mRNA inhibition
    17511001
    SM2549
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    2,3,6,7,9,12,13,14,15,16,17,18
    1,9,10,12,15,16,19
    Sugar
    Sugar
    28 percent target mRNA inhibition
    17511001
    SM2550
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    Sugar
    Sugar
    40 percent target mRNA inhibition
    17511001
    SM2551
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    1,9,10,12,15,16,19
    Sugar
    Sugar
    39 percent target mRNA inhibition
    17511001
    SM2552
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    Sugar
    Sugar
    18 percent target mRNA inhibition
    17511001
    SM2556
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    0
    2-Deoxy-2-Fluoro
    0
    1,9,10,12,15,16,19
    0
    Sugar
    60 percent target mRNA inhibition
    17511001
    SM2557
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    0
    2-Deoxy-2-Fluoro
    0
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    0
    Sugar
    55 percent target mRNA inhibition
    17511001
    SM2558
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    2,3,6,7,9,12,13,14,15,16,17,18
    1,9,10,12,15,16,19
    Sugar
    Sugar
    60 percent target mRNA inhibition
    17511001
    SM2559
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    Sugar
    Sugar
    70 percent target mRNA inhibition
    17511001
    SM2560
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    1,9,10,12,15,16,19
    Sugar
    Sugar
    66 percent target mRNA inhibition
    17511001
    SM2561
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    2,3,6,7,9,12,13,14,15,16,17,18
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    Sugar
    Sugar
    38 percent target mRNA inhibition
    17511001
    SM2565
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    0
    2-Deoxy-2-Fluoro
    0
    1,9,10,12,15,16,19
    0
    Sugar
    78 percent target mRNA inhibition
    17511001
    SM2566
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    0
    2-Deoxy-2-Fluoro
    0
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    0
    Sugar
    76 percent target mRNA inhibition
    17511001
    SM2567
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    2,3,6,7,9,12,13,14,15,16,17,18
    1,9,10,12,15,16,19
    Sugar
    Sugar
    77 percent target mRNA inhibition
    17511001
    SM2568
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    Sugar
    Sugar
    81 percent target mRNA inhibition
    17511001
    SM2569
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    1,9,10,12,15,16,19
    Sugar
    Sugar
    80 percent target mRNA inhibition
    17511001
    SM2570
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    2,3,6,7,9,12,13,14,15,16,17,18
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    Sugar
    Sugar
    68 percent target mRNA inhibition
    17511001
    SM2574
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    0
    2-Deoxy-2-Fluoro
    0
    1,9,10,12,15,16,19
    0
    Sugar
    81 percent target mRNA inhibition
    17511001
    SM2575
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    0
    2-Deoxy-2-Fluoro
    0
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    0
    Sugar
    87 percent target mRNA inhibition
    17511001
    SM2576
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    2,3,6,7,9,12,13,14,15,16,17,18
    1,9,10,12,15,16,19
    Sugar
    Sugar
    62 percent target mRNA inhibition
    17511001
    SM2577
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    Sugar
    Sugar
    71 percent target mRNA inhibition
    17511001
    SM2578
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    1,4,5,8,10,11,19,20,21
    1,9,10,12,15,16,19
    Sugar
    Sugar
    83 percent target mRNA inhibition
    17511001
    SM2579
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    2,3,6,7,9,12,13,14,15,16,17,18
    2,3,4,5,6,7,8,11,13,14,17,18,20,21
    Sugar
    Sugar
    69 percent target mRNA inhibition
    17511001
    SM3444
    AGCGCUUAAAGGGCGAGAAGAUU
    UCUUCUCGCCCUUUAAGCGCUUU
    2-Deoxy-2-Fluoro
    2-Deoxy-2-Fluoro
    7
    14,15
    Sugar
    Sugar
    44 percent target mRNA inhibition
    US20120088815A1, EP2415869A1