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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
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  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for Difluorotoluyl nucleotide are 7
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2596
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Difluorotoluyl nucleotide
    0
    9
    0
    Base
    5 percent target mRNA inhibition
    17881374
    SM2597
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Difluorotoluyl nucleotide
    0
    10
    0
    Base
    57 percent target mRNA inhibition
    17881374
    SM2598
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Difluorotoluyl nucleotide
    0
    11
    0
    Base
    2 percent target mRNA inhibition
    17881374
    SM2602
    GCGGAUCAAACCUCACCAATT
    UUGGUGAGGUUUGAUCCGCTT
    0
    Difluorotoluyl nucleotide
    0
    10
    0
    Base
    74 percent target mRNA inhibition
    17881374
    SM2603
    GCGGAUCAAACCUCACCAATT
    UUGGUGAGGUUUGAUCCGCTT
    0
    Difluorotoluyl nucleotide
    0
    11
    0
    Base
    69 percent target mRNA inhibition
    17881374
    SM2604
    GCGGAUCAAACCUCACCAATT
    UUGGUGAGGUUUGAUCCGCTT
    0
    Difluorotoluyl nucleotide
    0
    12
    0
    Base
    75 percent target mRNA inhibition
    17881374
    SM2605
    GCGGAUCAAACCUCACCAATT
    UUGGUGAGGUUUGAUCCGCTT
    0
    Difluorotoluyl nucleotide
    0
    10,11,12
    0
    Base
    28 percent target mRNA inhibition
    17881374