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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 1 are 85
    Results from 50 - 75
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2230
    CUGGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    5-Cholesterol
    5-Amino
    1
    1
    Sugar
    Sugar
    56 percent target mRNA inhibition
    17894530
    SM2231
    CUGGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    5-Cholesterol
    3-Amino
    1
    1
    Sugar
    Sugar
    49 percent target mRNA inhibition
    17894530
    SM2232
    CUGGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    5-Thio
    5-Thio
    1
    1
    Sugar
    Sugar
    68 percent target mRNA inhibition
    17894530
    SM2233
    CUGGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    0
    5-Thio
    0
    1
    0
    Sugar
    66 percent target mRNA inhibition
    17894530
    SM2465
    CGGAGGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Assymetric siRNA (3-End Overhang)
    Assymetric siRNA (3-End Overhang)
    21
    1
    NA
    NA
    60 percent target mRNA inhibition
    23135004
    SM2466
    GAGGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Assymetric siRNA (3-End Overhang)
    Assymetric siRNA (3-End Overhang)
    19
    1
    NA
    NA
    74 percent target mRNA inhibition
    23135004
    SM2467
    AGGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Assymetric siRNA (3-End Overhang)
    Assymetric siRNA (3-End Overhang)
    18
    1
    NA
    NA
    18 percent target mRNA inhibition
    23135004
    SM2468
    GGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Assymetric siRNA (3-End Overhang)
    Assymetric siRNA (3-End Overhang)
    17
    1
    NA
    NA
    16 percent target mRNA inhibition
    23135004
    SM2469
    GCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Assymetric siRNA (3-End Overhang)
    Assymetric siRNA (3-End Overhang)
    16
    1
    NA
    NA
    10 percent target mRNA inhibition
    23135004
    SM2470
    CUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Assymetric siRNA (3-End Overhang)
    Assymetric siRNA (3-End Overhang)
    15
    1
    NA
    NA
    14 percent target mRNA inhibition
    23135004
    SM2586
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    2,4-Difluorotoluene
    0
    1
    0
    Base
    IC-50 = 0.27 nM for target mRNA
    17163665
    SM2648
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Morpholinouridine
    0
    1
    0
    Sugar
    8 percent target mRNA inhibition
    19233658
    SM2849
    CAAGUGUCAUCACACUGAATT
    UUCAGUGUGAUGACACUUGTT
    0
    Hypoxanthine
    0
    1
    0
    Base
    58 percent target mRNA inhibition
    21942264
    SM2889
    CAAGUGUCAUCACACUGAATT
    UUCAGUGUGAUGACACUUGTT
    0
    2-O-Benzyl
    0
    1
    0
    Sugar
    24 percent target mRNA inhibition
    21942264
    SM2953
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    1
    0
    Sugar
    0 percent target mRNA inhibition
    19917641
    SM2973
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    1
    0
    Sugar
    87 percent target mRNA inhibition (IC-50 = 0.26 nM)
    19917641
    SM3116
    ACCUGACGUUGUACAAAUUTT
    AAUUUGUACAACGUCAGGUTT
    0
    4-Methylbenzimidazole
    0
    1
    0
    Base
    82 percent target mRNA inhibition
    18624291
    SM3343
    AGACGAGCUGAGCGAGAAGTT
    TTUCUGCUCGACUCGCUCUUC
    Locked nucleic acid
    Locked nucleic acid
    21
    1
    Sugar
    Sugar
    NA
    12834349
    SM3356
    AGACGAGCUGAGCGAGAAGTT
    TTUCUGCUCGACUCGCUCUUC
    0
    2-Deoxy-2-fluorouridine
    0
    1
    0
    Sugar
    NA
    12834349
    SM3362
    AGACGAGCUGAGCGAGAAGTT
    TTUCUGCUCGACUCGCUCUUC
    2-Deoxy-2-fluorouridine
    2-Deoxy-2-fluorouridine
    21
    1
    Sugar
    Sugar
    NA
    12834349
    SM3367
    CUUACGCUGAGUACUUCGAUU
    UUGAAUGCGACUCAUGAAGCU
    Methyleneamide
    Methyleneamide
    20
    1
    Sugar
    Sugar
    NA
    18066804
    SM3389
    GGACCACCGCAUCUCUACATT
    GGACCACCGCAUCUCUACATT
    0
    Galactose
    0
    1
    0
    Sugar
    NA
    20704260
    SM3391
    GGACCACCGCAUCUCUACATT
    GGACCACCGCAUCUCUACATT
    Galactose
    Galactose
    21
    1
    Sugar
    Sugar
    NA
    20704260
    SM3433
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate
    0
    1
    0
    Sugar
    IC-50 = 460 nM for target mRNA
    US8394947, EP1765074B1
    SM3810
    GCAAGUGGCAAGAGGAUUATT
    UAAUCCUCUUGCCACUUGCTT
    2-O-Methyl
    2-O-Methyl
    18
    1
    Sugar
    Sugar
    69 percent target mRNA inhibition
    US20120088815A1, EP2415869A1