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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 0 are 634
    Results from 525 - 550
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4347
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 18,19,20
    0
    Sugar ; Phosphate
    10 percent target mRNA inhibition
    15974578
    SM4348
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 1,2,3
    0
    Sugar ; Phosphate
    15 percent target mRNA inhibition
    15974578
    SM4349
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 3,4,5
    0
    Sugar ; Phosphate
    20 percent target mRNA inhibition
    15974578
    SM4350
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 6,7,8
    0
    Sugar ; Phosphate
    45 percent target mRNA inhibition
    15974578
    SM4351
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 9,10,11
    0
    Sugar ; Phosphate
    50 percent target mRNA inhibition
    15974578
    SM4352
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 12,13,14
    0
    Sugar ; Phosphate
    36 percent target mRNA inhibition
    15974578
    SM4353
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 15,16,17
    0
    Sugar ; Phosphate
    44 percent target mRNA inhibition
    15974578
    SM4354
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-(2-methoxyethyl)ribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 * 18,19,20
    0
    Sugar ; Phosphate
    17 percent target mRNA inhibition
    15974578
    SM4456
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    0
    Palmitic Acid
    0
    21
    0
    Phosphate
    82 percent target mRNA inhibition
    21985606
    SM4600
    GGCCUUUCACUACUCCUACTT
    AGUAGGAGUAGUGAAAGGCCTT
    0
    4-C- Aminomethyl-2-O-Methylribose
    0
    20
    0
    Sugar
    95 percent target mRNA inhibition
    22372696
    SM4601
    GGCCUUUCACUACUCCUACTT
    AGUAGGAGUAGUGAAAGGCCUT
    0
    4-C- Aminomethyl-2-O-Methylribose
    0
    3,21
    0
    Sugar
    66 percent target mRNA inhibition
    22372696
    SM4605
    GGCCUUUCACUACUCCUACT
    AGUAGGAGUAGUGAAAGGCCUT
    0
    2-O-Methyl
    0
    3,21
    0
    Sugar
    94 percent target mRNA inhibition
    22372696
    SM4660
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid* Thymidine
    0
    10 * 10
    0
    Sugar ; Base
    95 percent target mRNA inhibition
    US 20080249039 A1
    SM4661
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    2
    0
    Sugar
    0 percent target mRNA inhibition
    US 20080249039 A1
    SM4662
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    3
    0
    Sugar
    82 percent target mRNA inhibition
    US 20080249039 A1
    SM4663
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    4
    0
    Sugar
    85 percent target mRNA inhibition
    US 20080249039 A1
    SM4664
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    5
    0
    Sugar
    83 percent target mRNA inhibition
    US 20080249039 A1
    SM4665
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    6
    0
    Sugar
    82 percent target mRNA inhibition
    US 20080249039 A1
    SM4666
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    7
    0
    Sugar
    81 percent target mRNA inhibition
    US 20080249039 A1
    SM4667
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    8
    0
    Sugar
    86 percent target mRNA inhibition
    US 20080249039 A1
    SM4668
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    9
    0
    Sugar
    85 percent target mRNA inhibition
    US 20080249039 A1
    SM4669
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid* Thymidine
    0
    10 * 10
    0
    Sugar ; Base
    91 percent target mRNA inhibition
    US 20080249039 A1
    SM4670
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    11
    0
    Sugar
    50 percent target mRNA inhibition
    US 20080249039 A1
    SM4671
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    12
    0
    Sugar
    89 percent target mRNA inhibition
    US 20080249039 A1
    SM4672
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    13
    0
    Sugar
    65 percent target mRNA inhibition
    US 20080249039 A1